A Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish

Genon, Sarah; Bastin, Christine; Angel, Lucie; Collette, Fabienne; Bahri, Mohamed Ali; Salmon, Eric

doi:10.1016/j.cortex.2014.02.003

Cited by 4 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This contrasts with results from Genon et al (2014a, 2014b), where PCC activity was associated with the accurate recognition of self-referentially encoded information, rather than the SRE magnitude per se. Instead, SRE magnitude was associated with lateral PFC atrophy, which presumably mediates the interaction between self-referential and higher order cognitive processes (Genon et al, 2014a; Northoff et al, 2006).…”

Section: Discussioncontrasting

confidence: 99%

“…A follow-up investigation revealed a wider functional network of brain regions associated with the accurate recognition of self-referenced information, including the PCC and hippocampus in AD patients (Genon et al, 2014b). In the context of Northoff et al (2006) model, these findings (Genon et al, 2014a, 2014b) suggest that the absence of SRE in AD may not be related to impairments in the representation of stimuli as self-related by the anterior-ventral CMS, but rather, to a broader deficit in the retrieval of self-related memories, mediated by posterior CMS subregions known to be affected early in the course of the disease (Chételat et al, 2007; Irish, Addis, Hodges, & Piguet, 2012; Nestor, Fryer, Ikeda, & Hodges, 2003; Scahill, Schott, Stevens, Rossor, & Fox, 2002). This dovetails with previous reports of intact concept of self in AD (Eustache et al, 2013; Klein et al, 2003; Rankin, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia

Wong

Irish

Leshikar

et al. 2017

Cortex

View full text Add to dashboard Cite

Encoding information in reference to the self enhances subsequent memory for the source of this information. In healthy adults, self-referential processing has been proposed to be mediated by the cortical midline structures (CMS), with functional differentiation between anterior-ventral, anterior-dorsal and posterior regions. While both Alzheimer’s disease (AD) and behavioural-variant frontotemporal dementia (bvFTD) patients show source memory impairment, it remains unclear whether they show a typical memory advantage for self-referenced materials. We also sought to identify the neural correlates of this so-called ‘self-reference effect’ (SRE) in these patient groups. The SRE paradigm was tested in AD (n = 16) and bvFTD (n = 22) patients and age-matched healthy controls (n = 17). In this task, participants studied pictures of common objects paired with one of two background scenes (sources) under self-reference or other-reference encoding instructions, followed by an item and source recognition memory test. Voxel-based morphometry was used to investigate correlations between SRE measures and regions of grey matter atrophy in the CMS. The behavioural results indicated that self-referential encoding did not ameliorate the significant source memory impairments in AD and bvFTD patients. Furthermore, the reduced benefit of self-referential relative to other-referential encoding was not related to general episodic memory deficits. Our imaging findings revealed that reductions in the SRE were associated with atrophy in the anterior-dorsal CMS across both patient groups, with additional involvement of the posterior CMS in AD and anterior-ventral CMS in bvFTD. These findings suggest that although the SRE is comparably reduced in AD and bvFTD, this arises due to impairments in different subcomponents of self-referential processing.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia

Wong

Irish

Leshikar

et al. 2017

Cortex

View full text Add to dashboard Cite

show abstract

“…While some authors argue either for one or the other approach, the use of these approaches are far from being mutually exclusive (Moeller and Habeck, 2006). Combining both approaches in small datasets indeed revealed that the results of the univariate approach reflect the ‘tip of the iceberg’ of the behavior’s brain correlates, whose spatial extent are more comprehensively captured with the multivariate analysis, but interpretability is facilitated by the use of univariate analyses; for example (Genon et al, 2016; Genon et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Empirical examination of the replicability of associations between brain structure and psychological variables

Masouleh

Eickhoff

Hoffstaedter

et al. 2019

eLife

Self Cite

214

109

View full text Add to dashboard Cite

Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported ‘structural brain behavior’ (SBB)-associations has been questioned, recently. Here, we conducted an empirical investigation, assessing replicability of SBB among heathy adults. For a wide range of psychological measures, the replicability of associations with gray matter volume was assessed. Our results revealed that among healthy individuals 1) finding an association between performance at standard psychological tests and brain morphology is relatively unlikely 2) significant associations, found using an exploratory approach, have overestimated effect sizes and 3) can hardly be replicated in an independent sample. After considering factors such as sample size and comparing our findings with more replicable SBB-associations in a clinical cohort and replicable associations between brain structure and non-psychological phenotype, we discuss the potential causes and consequences of these findings.

show abstract

“…Combining both 398 approaches in small datasets indeed revealed that the results of the univariate approach reflect 399 the "tip of the iceberg" of the behavior's brain correlates, whose spatial extent are more 400 comprehensively captured with the multivariate analysis, but interpretability is facilitated by 401 the use of univariate analyses; e.g. (Genon et al, 2016(Genon et al, , 2014. 402…”

Section: Poor Spatial Overlap Of Sbb Across Resampling: Possible Causmentioning

confidence: 99%

Empirical examination of the replicability of associations between brain structure and psychological variables

Kharabian

Eickhoff

Hoffstaedter

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported “structural brain behavior” (SBB)-associations has been questioned, recently. Here, we conducted an empirical investigation, assessing replicability of SBB among heathy adults. For a wide range of psychological measures, the replicability of associations with gray matter volume was assessed. Our results revealed that among healthy individuals 1) finding an association between performance at standard psychological tests and brain morphology is relatively unlikely 2) significant associations, found using an exploratory approach, have overestimated effect sizes and 3) can hardly be replicated in an independent sample. After considering factors such as sample size and comparing our findings with more replicable SBB-associations in a clinical cohort and replicable associations between brain structure and non-psychological phenotype, we discuss the potential causes and consequences of these findings.

show abstract

A Partial Least Squares Analysis of the self reference effect in Alzheimer's disease: A reply to Irish

Cited by 4 publications

References 24 publications

The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia

The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia

Empirical examination of the replicability of associations between brain structure and psychological variables

Empirical examination of the replicability of associations between brain structure and psychological variables

Contact Info

Product

Resources

About