“…In most of the previous works on BAO, the entire range, [0 âą , 360 âą ] in the coplanar case, of gantry angles is discretized into equally spaced beam directions with a given angle increment, such as 5 or 10 degrees, where exhaustive searches are performed directly or guided by a variety of different heuristics including simulated annealing [7], genetic algorithms [19], particle swarm optimization [24] or other heuristics incorporating a priori knowledge of the problem [20]. Although those global heuristics can theoretically avoid local optima, globally optimal or even clinically better solutions cannot be obtained without a large number of objective function evaluations.…”