A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. Commentary for “Underground railway particulate matter and susceptibility to pneumococcal infection”

Håkansson, Anders P.

doi:10.1016/j.ebiom.2022.104116

Cited by 1 publication

(1 citation statement)

References 11 publications

(15 reference statements)

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“…LPS is a potent microbial inducer of inflammation, and recognition of LPS by the innate immune system is a crucial step in identifying invading gram-negative bacteria and in initiating a protective immune response; any impairment of this process may enhance susceptibility to certain infectious agents. The capacity of PM to increase susceptibility to infections has previously been shown for various gram-positive and gram-negative bacteria such as Mycobacterium tuberculosis 39 , Streptococcus pneumoniae 40 , and Pseudomonas aeruginosa 41 . Furthermore, case-crossover analyses conducted in the United States found that short-term exposure to PM 2.5 is associated with increased risk of hospital admissions due to septicaemia 42 .…”

Section: Discussionmentioning

confidence: 86%

Vitamin D3 regulates PM-driven primary human neutrophil inflammatory responses

Kewcharoenwong,

Khongmee,

Nithichanon

et al. 2023

Sci Rep

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Recent evidence has demonstrated that both acute and chronic exposure to particulate air pollution are risk factors for respiratory tract infections and increased mortality from sepsis. There is therefore an urgent need to establish the impact of ambient particulate matter (PM) on innate immune cells and to establish potential strategies to mitigate against adverse effects. PM has previously been reported to have potential adverse effects on neutrophil function. In the present study, we investigated the impact of standard urban PM (SRM1648a, NIST) and PM2.5 collected from Chiang Mai, Thailand, on human peripheral blood neutrophil functions, including LPS-induced migration, IL-8 production, and bacterial killing. Both NIST and the PM2.5, being collected in Chiang Mai, Thailand, increased IL-8 production, but reduced CXCR2 expression and migration of human primary neutrophils stimulated with Escherichia coli LPS. Moreover, PM-pretreated neutrophils from vitamin D-insufficient participants showed reduced E. coli-killing activity. Furthermore, in vitro vitamin D3 supplementation attenuated IL-8 production and improved bacterial killing by cells from vitamin D-insufficient participants. Our findings suggest that provision of vitamin D to individuals with insufficiency may attenuate adverse acute neutrophilic responses to ambient PM.

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