A patch type non-enzymatic biosensor based on 3D SUS micro-needle electrode array for minimally invasive continuous glucose monitoring

Lee, Su Jin; Yoon, Hyo Sang; Xing, Xuan; Park, Jae Young; Paik, Seung-Joon; Allen, Mark G.

doi:10.1016/j.snb.2015.08.013

Cited by 85 publications

(64 citation statements)

References 28 publications

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“…For this reason, many studies focus on the coating of MNs with conductive materials represented by Au, Pt, and Ag/AgCl as the WEs, counter electrodes (CEs), and reference electrodes (REs), respectively, in order to enable an MN to function as an electrochemical electrode. In this methodology, metal [ 40 – 46 ], epoxy [ 47 – 49 ], SU-8 [ 50 – 53 ], and polymer [ 53 – 59 ] MNs are coated with metal layers using electroplating or vapor deposition. The covering metal layers are connected to the extract electrodes and the measurement system to conduct the input and output signals.…”

Section: Mns As Sensing Probesmentioning

confidence: 99%

Functionalized microneedles for continuous glucose monitoring

Takeuchi

Kim

2018

Nano Convergence

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Microneedles (MNs) have been established as promising medical devices as they are minimally invasive, cause less pain, and can be utilized for self-administration of drugs by patients. There has been rapid development in MNs for transdermal monitoring and diagnostic systems, following the active research on fabrication methods and applications for drug delivery. In this paper, recent investigations on bio-sensing using MNs are reviewed in terms of the applicability to continuous glucose monitoring system (CGMS), which is one of the main research focuses of medical engineering technologies. The trend of the functionalized MNs can be categorized as follows: (i) as a sensing probe, and (ii) as a biological fluid collector. MNs as in vivo sensors are mainly integrated or coated with conductive materials to have the function as electrodes. MNs as fluid collectors are given a certain geometrical design, such as a hollow and porous structure aided by a capillary action or negative pressure, to extract the interstitial fluids or blood for ex vivo analysis. For realization of CGMS with MNs, a long-term accurate measurement by the MN-based sensing probe or a fluidic connection between the MN-based fluid collector and the existing microfluidic measurement systems should be investigated.

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Section: Mns As Sensing Probesmentioning

confidence: 99%

Functionalized microneedles for continuous glucose monitoring

Takeuchi

Kim

2018

Nano Convergence

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“…Enzymatic catalysts usually possess high selectivity and catalytic effectivity, and are suitable for most biomedical applications. Representatives of non-enzymatic catalysts are nanomaterials including nanoporous Pt [113], Pt black [114], Pd nanoclusters [115], and so on. Compared with the enzymatic catalyst, the non-enzymatic catalyst has better stability, less environmental requirements, and is easier to store.…”

Section: Electrochemistrymentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…70 The microneedles were patterned from 316-L grade stainless-steel by using jet of ferric chloride wet chemical etchant under the pressure of 2 kg f cm −2 for 60 s. The needles were then punched-out to bend them to 90…”

Section: In-vivo Non-enzymatic Microneedle Glucose Sensorsmentioning

confidence: 99%

Editors' Choice—Review—In Vivo and In Vitro Microneedle Based Enzymatic and Non-Enzymatic Continuous Glucose Monitoring Biosensors

Chinnadayyala

Park

Cho

2018

ECS J. Solid State Sci. Technol.

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Microneedles have emerged for transdermal monitoring of biomarkers, which are a miniaturized replica of hypodermic needles with length-scales of hundreds of micrometers, with a goal to achieve time-sensitive clinical information for routine point-of-care health monitoring. Transdermal biosensing via microneedles offers remarkable opportunities for moving biosensing technologies from research laboratories to real-field applications and enables development of easy-to-use point-of-care microdevices, minimally invasive, and with minimal-training features that are very attractive for both developed and emerging countries. This would eliminate the need for blood extraction using hypodermic needles and in turn, reduce the related problems such as infections in the patients, sample contaminations, and analysis artifacts. In this review, we provide a general overview of recent progress in microneedlebased sensing research, including: (a) in-vivo microneedle diagnostic systems for glucose monitoring with an emphasis on sensor construction and general health monitoring (b) in-vitro use of microneedle sensors. The main objective of the review is to provide a thorough and critical analysis of recent advances and developments in microneedle research field and to bridge the gap between microneedles and biosensors.

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A patch type non-enzymatic biosensor based on 3D SUS micro-needle electrode array for minimally invasive continuous glucose monitoring

Cited by 85 publications

References 28 publications

Functionalized microneedles for continuous glucose monitoring

Functionalized microneedles for continuous glucose monitoring

Engineering Microneedles for Therapy and Diagnosis: A Survey

Editors' Choice—Review—In Vivo and In Vitro Microneedle Based Enzymatic and Non-Enzymatic Continuous Glucose Monitoring Biosensors

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