A pathological perspective to painful inguinal hernia: Report of two cases

Narita, Michiko; Moriyoshi, Koki; Goto, Kentaro; Yamaoka, Ryoya; Yamaguchi, Takashi

doi:10.1016/j.ijscr.2021.106389

Cited by 3 publications

References 10 publications

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Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain: it’s the sign of irreversible nerve injury, isn’t it?

Narita,

Moriyoshi,

Yamaoka

et al. 2023

Langenbecks Arch Surg

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Preoperative pain is known as the most powerful risk factor for chronic postoperative inguinal pain (CPIP), while its pathogenesis has not been fully elucidated. The aim of the present study was to evaluate patients with preoperative pain from the pathological perspective and discuss the potential pathogenesis of CPIP in those patients. MethodsThis was a single-institutional retrospective study. The study population was inguinal hernia patients with preoperative pain who underwent open anterior hernia repair for primary inguinal hernia with pragmatic ilioinguinal neurectomy during surgery between March 2021 and March 2023. The primary and secondary outcomes were proportion of collagen deposition and mucus accumulation within ilioinguinal nerve in those patients, respectively, which were evaluated histologically using Image J software. ResultsForty patients were evaluated. Median value of proportion of intraneural collagen deposition was 38.3 (27.7-95.9) %. These values were positively correlated with the duration of pain (r 2 =0.468, P<0.001).Median value of proportion of mucus accumulation in ilioinguinal nerve was 50.1 (0-82.0) %. These values had no correlation with any clinicopathological variables. ConclusionsIn the present study population, all patients with preoperative pain had intraneural brosis within ilioinguinal nerve, and its degree had a signi cantly positive correlation with the pain duration. These results suggest that nerve injury may be irreversible and open anterior hernia repair with a planned ilioinguinal neurectomy may be a good option for patients with long-term preoperative pain to prevent persistent pain that being present preoperatively.

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Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain: it’s the sign of irreversible nerve injury, isn’t it?

Narita,

Moriyoshi,

Yamaoka

et al. 2023

Langenbecks Arch Surg

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View full text Add to dashboard Cite

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Perioperative Risk Factors for Persistent Postsurgical Pain After Inguinal Hernia Repair: Systematic Review and Meta-Analysis

Alaverdyan,

Maeng,

Park

et al. 2024

The Journal of Pain

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Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain -It’s the sign of irreversible nerve injury, isn’t it?

Narita,

Moriyoshi,

Yamaoka

et al. 2023

Preprint

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Purpose Preoperative pain is known as the most powerful risk factor for chronic postoperative inguinal pain (CPIP), while its pathogenesis has not been fully elucidated. The aim of the present study was to evaluate patients with preoperative pain from the pathological perspective and discuss the potential pathogenesis of CPIP in those patients. Methods This was a single-institutional retrospective study. The study population was inguinal hernia patients with preoperative pain who underwent open anterior hernia repair for primary inguinal hernia with pragmatic ilioinguinal neurectomy during surgery between March 2021 and March 2023. The primary and secondary outcomes were proportion of collagen deposition and mucus accumulation within ilioinguinal nerve in those patients, respectively, which were evaluated histologically using Image J software. Results Forty patients were evaluated. Median value of proportion of intraneural collagen deposition was 38.3 (27.7-95.9) %. These values were positively correlated with the duration of pain (r2=0.468, P<0.001). Median value of proportion of mucus accumulation in ilioinguinal nerve was 50.1 (0-82.0) %. These values had no correlation with any clinicopathological variables. Conclusions In the present study population, all patients with preoperative pain had intraneural fibrosis within ilioinguinal nerve, and its degree had a significantly positive correlation with the pain duration. These results suggest that nerve injury may be irreversible and open anterior hernia repair with a planned ilioinguinal neurectomy may be a good option for patients with long-term preoperative pain to prevent persistent pain that being present preoperatively.

show abstract

A pathological perspective to painful inguinal hernia: Report of two cases

Cited by 3 publications

References 10 publications

Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain: it’s the sign of irreversible nerve injury, isn’t it?

Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain: it’s the sign of irreversible nerve injury, isn’t it?

Perioperative Risk Factors for Persistent Postsurgical Pain After Inguinal Hernia Repair: Systematic Review and Meta-Analysis

Intraneural fibrosis within ilioinguinal nerve in inguinal hernia patients with preoperative pain -It’s the sign of irreversible nerve injury, isn’t it?

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