A pathomorphological characteristic of inflammatory process in the gastric mucosa in chronic gastroduodenitis in children

Spivak, E.M.; Levit, Romina; Хавкин, А.И.; Akkuratova, I. S.; Nadezhin, Alexander S.

doi:10.20953/1727-5784-2013-6-24-27

Vopr. det. dietol.

2013

DOI: 10.20953/1727-5784-2013-6-24-27

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A pathomorphological characteristic of inflammatory process in the gastric mucosa in chronic gastroduodenitis in children

E.M. Spivak¹,

Romina Levit²,

А.И. Хавкин³

et al.

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2022

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Cellular composition of gastric glands in chronic gastritis among children

Akkuratova-Maksimova¹,

Manyakina²,

Shkolina³

2022

Perm Medical Journal

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Objective. To establish the features of the cellular composition of gastric mucosa glands in chronic Hp-associated gastritis among children to improve its diagnostics. Material and methods. Morphometric analysis of fundal and pyloric gland cell populations was performed in 214 children aged 615 years with Hp-associated chronic gastritis. For this purpose, the number of main, parietal, endocrine and additional cells was calculated in the materials of gastrobiopsy of the gastric mucosa, the result was expressed in (per 1000 epithelial cells). Results. It was found that as the severity of inflammation in the fundal glands increases, the number of main cells decreases, the number of parietal, accessory and especially endocrine cells grows. In the pyloric glands, a reduction of the parietal pool, a decrease in the population of additional cells and a sharp increase in endocrinocytes is registered. With a decrease in the severity of inflammation, positive changes in the cellular composition of the glands are observed, but its full normalization does not occur 6 months after the course of antihelicobacter therapy. A significant proportion of patients, shows morphological signs of gastric mucosa atrophy, which is associated with inflammation and is uncertain. Its presence does not significantly affect the cellular composition of the gastric glands, and the regression of the inflammatory process is accompanied by a decrease in the degree of atrophy or complete disappearance of signs of the latter. Conclusions. The addition of a standard study of gastrobioptates with a quantitative morphometric analysis of the cellular composition of the fundal and pyloric glands in chronic gastritis among children objectifies the data of morphological assessment of pathohistological picture of gastric mucosa.

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Cellular composition of gastric glands in chronic gastritis among children

Akkuratova-Maksimova¹,

Manyakina²,

Shkolina³

2022

Perm Medical Journal

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Patterns of changes in cellular composition of the stomach in chronic gastritis in children and adolescents

Spivak

Хавкин

2022

jour

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The aim of the work is to establish the regularities of changes in the cellular composition of the fundal and pyloric glands in chronic gastritis in children. Material and methods. 213 patients aged 7-17 years with chronic Hp-associated gastritis were examined. The cellular composition of the fundal and pyloric glands was determined in gastrobioptates. Immunohistochemical analysis was used to determine cells containing gastrin, somatostatin, pepsinogens I and II, acidic and neutral mucins. The results were expressed in‰ per 1000 epithelial cells. Results. As inflammation increases in the fundal glands, the number of main and cells containing pepsinogens I and II decreases, the number of lining, additional and endocrine cells increases. In the pyloric glands, the pool of endocrinocytes increases, the number of lining cells and cells immunopositive to pepsinogen II significantly decreases. Parallel to the severity of the process, there is a sharp increase in D- and G-cells and an increase in the number of epithelial cells containing acidic and neutral mucins. Conclusion. Chronic inflammation of the gastric mucosa is accompanied by a significant restructuring of the cellular composition of its glands.

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A pathomorphological characteristic of inflammatory process in the gastric mucosa in chronic gastroduodenitis in children

Cited by 2 publications

References 0 publications

Cellular composition of gastric glands in chronic gastritis among children

Cellular composition of gastric glands in chronic gastritis among children

Patterns of changes in cellular composition of the stomach in chronic gastritis in children and adolescents

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