Diabetes is one of the most significant global health emergencies affecting populations in the 21st century, where one out of 15 adults has type II diabetes. Impaired glucose tolerance contributes to more than half of all causes of diabetes. Further, depression has adverse economic and health outcomes. The condition also contributes to poor outcomes in screening efforts among type II diabetes patients. E-health intervention is one of the means for reducing depression. There is, therefore, a need to investigate whether the strategy effectively reduces depression among patients with type II diabetes. The research examined the e-health interventions, which include personal health records (PHRs), diabetes mobile apps, patient portals, information repositories, telehealth, and electronic health records (EHRs). The research findings indicated that e-health would significantly help in reducing depression among people with type II diabetes.