A patient with a juxtaglomerular cell tumor with histological vascular invasion

Beaudoin, Jonathan; Périgny, Martine; Têtu, Bernard; Lebel, Marcel

doi:10.1038/ncpneph0890

Cited by 23 publications

(20 citation statements)

References 15 publications

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“…Mast cells often infiltrate in the stroma [4,36]. Penetration of fibrous capsule or vascular invasion by tumor cells may be observed in some cases [37-39](Figure 3). …”

Section: Introductionmentioning

confidence: 99%

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

et al. 2011

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Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.

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“…Mast cells often infiltrate in the stroma [4,36]. Penetration of fibrous capsule or vascular invasion by tumor cells may be observed in some cases [37-39](Figure 3). …”

Section: Introductionmentioning

confidence: 99%

Review of juxtaglomerular cell tumor with focus on pathobiological aspect

et al. 2011

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“…Only two case reports have suggested vascular invasion and questioned its benign nature. [1314] But in our patient, since malignancy could not be ruled out and the mass being located at hilum, kidney had to be sacrificed. It was only after histopathology that the diagnosis was made.…”

Section: Discussionmentioning

confidence: 87%

“…[10] The tumor mass in our patient was one of the largest sizes of JCTs reported in literature. Reninomas are usually small tumors, peripherally located, and usually have a largest diameter of 2 to 3 cm,[14] and the only tumor of comparable size (9.8 cm) has been reported by Beaudoin et al . in 2008.…”

Section: Discussionmentioning

confidence: 99%

Recurrent malignant juxtaglomerular cell tumor: A rare cause of malignant hypertension in a child

Shera

Baba

Bakshi

et al. 2011

J Indian Assoc Pediatr Surg

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“…However, there is a report of a very unusual case of a metastazing JGCT by Duan et al [3]. Vascular and capsular invasion, as a possible sign of aggressive behavior, has also been documented [7,8]. Clinical behavior otherwise can be malignant due to severe systemic complications of hypertension.…”

Section: Discussionmentioning

confidence: 93%