A patient with concurrent prurigo nodularis and squamous cell carcinomas of keratoacanthoma type: The role of aprepitant in diagnostic clarity

Evaluation of risk in chronic cutaneous inflammatory conditions for malignant transformation

“…Additionally, there is one case report and one case series demonstrating the occurrence of SCC in the setting of PN. One case report evaluates an elderly HIV male patient with a year long history of generalized pruritus and diffuse hyperkeratotic papules that were later biopsy‐proven to be keratoacanthoma‐type SCC 117 . Although no causal relationship can be determined, this report demonstrates the occurrence of skin cancer and the complicated task of differentiating PN from malignant lesions.…”

“…110,114 It typically affects middleaged adults and occurs more commonly in females and persons with skin of colour, including African Americans. 115 Currently in the literature, there is one cross-sectional study evaluating the association between PN and skin malignancies in 695 PN patients from the John Hopkins Health System between 2013 and 2017. 116 They reported that in these patients, SCC, BCC and malignant melanoma had a higher prevalence when compared to the general population.…”