A patient with Parkinson’s disease benefits from spinal cord stimulation

Hassan, Syed Shams ul; Amer, Syed; Alwaki, AbdulRehman; Elborno, Ahmed

doi:10.1016/j.jocn.2012.08.018

Cited by 54 publications

(42 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar observation was made in a 68-year-old patient with PD who underwent SCS at the T9-T11 level for postlaminectomy neuropathic pain and whose parkinsonian symptoms, particularly tremor, were improved when the stimulation was switched on [14]. Additionally, a 43-year-old woman with PD who benefited from stimulation at the C2 level for neck and upper extremity neurogenic pain displayed a 40 % improvement in the motor UPDRS-III score following SCS [15]. A larger Japanese study of 15 patients with PD suffering from neuropathic pain and treated with thoracic SCS using percutaneous leads showed some improvement in PD symptoms [16].…”

Section: Human Studiessupporting

confidence: 66%

“…All these reports suggest that the quality of levodopa response may account for the level of motor effect following SCS. It is also likely that SCS affects PD symptoms differently, as tremor was the most responsive symptom [13][14][15].…”

Section: Human Studiesmentioning

confidence: 99%

“…The technique consists of inserting an epidural lead containing multiple stimulating electrodes (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The leads can be percutaneous or surgical paddle leads.…”

Section: Introductionmentioning

confidence: 99%

“…Subsequent open-label clinical trials using SCS have emerged in different types of movement disorders, as illustrated by the publication of large series of patients, up to 1336, operated between 1972 and 1997 [9]. More recently, promising studies in animal models of Parkinson's disease (PD) brought SCS up to date in movement disorders [10,11], followed quickly by case reports in patients suffering from PD [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spinal Stimulation for Movement Disorders

et al. 2014

View full text Add to dashboard Cite

Epidural spinal cord stimulation (SCS) is currently proposed to treat intractable neuropathic pain. Since the 1970s, isolated cases and small cohorts of patients suffering from dystonia, tremor, painful leg and moving toes (PLMT), or Parkinson's disease were also treated with SCS in the context of exploratory clinical studies. Despite the safety profile of SCS observed in these various types of movement disorders, the degree of improvement of abnormal movements following SCS has been heterogeneous among patients and across centers in open-label trials, stressing the need for larger, randomized, double-blind studies. This article provides a comprehensive review of both experimental and clinical studies of SCS application in movement disorders.

show abstract

Section: Human Studiessupporting

confidence: 66%

Section: Human Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spinal Stimulation for Movement Disorders

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In PD, a similar approach using spinal cord stimulation (SCS) has been tested for the purpose of interfering with synchronized low-frequency oscillations characteristic of the parkinsonian state. Good results were initially achieved in rodent models of PD (Fuentes et al, 2009), and more recently, clinically validated effects have also been reported ( Agari and Date, 2012;F é nelon et al, 2012;Hassan et al, 2013; see also Nicolelis et al, 2010). In the treatment of levodopa-induced dyskinesia, however, stimulation of afferent pathways remains to be evaluated.…”

Section: Breaking the Waves -A Neuromodulatory Approachmentioning

confidence: 99%

Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

Richter

Halje

Petersson

2013

Reviews in the Neurosciences

View full text Add to dashboard Cite

A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.

show abstract

A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies

Hvingelby,

Carra,

Terkelsen

et al. 2024

Movement Disord Clin Pract

View full text Add to dashboard Cite

BackgroundParkinson's Disease (PD) is a progressive neurological disorder that results in potentially debilitating mobility deficits. Recently, spinal cord stimulation (SCS) has been proposed as a novel therapy for PD gait disorders. The highest levels of evidence remain limited for SCS.ObjectivesIn this systematic review and narrative synthesis, the literature was searched using combinations of key phrases indicating spinal cord stimulation and PD.MethodsWe included pre‐clinical studies and all published clinical trials, case reports, conference abstracts as well as protocols for ongoing clinical trials. Additionally, we included trials of SCS applied to atypical parkinsonism.ResultsA total of 45 human studies and trials met the inclusion criteria. Based on the narrative synthesis, a number of knowledge gaps and future avenues of potential research were identified. This review demonstrated that evidence for SCS is currently not sufficient to recommend it as an evidence‐based therapy for PD related gait disorders. There remain challenges and significant barriers to widespread implementation, including issues regarding patient selection, effective outcome selection, stimulation location and mode, and in programming parameter optimization. Results of early randomized controlled trials are currently pending. SCS is prone to placebo, lessebo and nocebo as well as blinding effects which may impact interpretation of outcomes, particularly when studies are underpowered.ConclusionTherapies such as SCS may build on current evidence and be shown to improve specific gait features in PD. Early negative trials should be interpreted with caution, as more evidence will be required to develop effective methodologies in order to drive clinical outcomes.

show abstract

A patient with Parkinson’s disease benefits from spinal cord stimulation

Cited by 54 publications

References 9 publications

Spinal Stimulation for Movement Disorders

Spinal Stimulation for Movement Disorders

Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies

Contact Info

Product

Resources

About