A patient with secondary syphilis following incomplete treatment of primary infection

Lorenz, Zachary; Rybolt, Lauren E; Ghanem, Khalil G.; Shiroky-Kochavi, Jennifer

doi:10.1016/s1473-3099(23)00211-6

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…The general topic of vaccines for T. pallidum has been thoroughly addressed elsewhere and here will not go into more detail (136, 146). T. pallidum is primarily transmitted through skin-to-skin or mucosal contact during sexual encounters, as well as through vertical transmission (147). Over the past three decades, public attention to sexually transmitted infections has focused primarily on HIV infection, while other infections such as syphilis have gradually been marginalized (148).…”

Section: Administrationmentioning

confidence: 99%

Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention

Wu,

Ye,

Wang

et al. 2024

Front. Neurol.

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Background and aimInvasion of the central nervous system by Treponema pallidum can occur at any stage of syphilis. In the event that T. pallidum is not cleared promptly, certain individuals may experience progression to neurosyphilis, which manifests as cognitive and behavioral abnormalities, limb paralysis, and potentially fatal outcomes. Early identification or prevention of neurosyphilis is therefore crucial. The aim of this paper is to conduct a critical and narrative review of the latest information focusing exclusively to the pathogenesis and clinical management of neurosyphilis.MethodologyTo compile this review, we have conducted electronic literature searches from the PubMed database relating to neurosyphilis. Priority was given to studies published from the past 10 years (from 2013 to 2023) and other studies if they were of significant importance (from 1985 to 2012), including whole genome sequencing results, cell structure of T. pallidum, history of genotyping, and other related topics. These studies are classic or reflect a developmental process.ResultsNeurosyphilis has garnered global attention, yet susceptibility to and the pathogenesis of this condition remain under investigation. Cerebrospinal fluid examination plays an important role in the diagnosis of neurosyphilis, but lacks the gold standard. Intravenous aqueous crystalline penicillin G continues to be the recommended therapeutic approach for neurosyphilis. Considering its sustained prominence, it is imperative to develop novel public health tactics in order to manage the resurgence of neurosyphilis.ConclusionThis review gives an updated narrative description of neurosyphilis with special emphasis on its pathogenesis, susceptibility, diagnosis, treatment, and prevention.

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Section: Administrationmentioning

confidence: 99%