A patient with squamous cell carcinoma <i>in-situ</i> successfully treated with intralesional 5-Fluorouracil and topical trichloroacetic acid

Vazquez, Thomas; Flórez-White, Mercedes

doi:10.1080/09546634.2019.1589642

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…The size of the lesion may also play a role in determining the volume of the 5-FU injection. Furthermore, in a case report by Vazquez et al, a 96-year-old male presented with a cSCC on the lower extremity and was treated with a similar method to our patient using lidocaine for the anesthetic and multiple injections of 5-FU 50 mg/mL solution for 1.5 mL in total [ 11 ]. Compared to the 98-year-old female patient in our case report, this was the same amount of 5-FU.…”

Section: Discussionmentioning

confidence: 99%

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Intralesional 5-Fluorouracil in the Treatment of Squamous Cell Carcinoma in an Elderly Patient

McDonald,

Neidenbach

2024

Cureus

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Squamous cell carcinoma (SCC) is the second leading form of skin cancer. In the elderly population, surgery may carry more risk and significant morbidity in comparison to less invasive forms of treatment. This case report describes the successful use of intralesional 5-fluorouracil (IL5-FU) to treat cutaneous squamous cell carcinoma (cSCC). A 98-year-old white woman presented in early May 2017 with a 3.5-cm rapidly growing crusted nodule on her left proximal-lateral arm. She had a past medical history of chronic obstructive pulmonary disease, atrial fibrillation, and heart failure. The patient also had a frail body habitus and weighed 80 pounds. Physical examination revealed a large, ulcerated, crateriform mass on the left proximal-lateral arm. A shave biopsy was performed, which revealed a well-differentiated SCC, composed of nodular masses of neoplastic squamous cells with atypical nuclei, keratin pearl formation, and scattered mitotic figures with surrounding fibrosis and inflammation. The patient was wheelchair-bound and oxygen-dependent and, thus, not considered a good surgical or radiation candidate. Treatment was decided with 5-fluorouracil. At a four-week follow-up appointment, there was no visible or palpable evidence of the tumor. There was no sign of recurrence at three months, indicating treatment success. The patient later died due to cardiac arrest in September 2017. The elderly population with cSCC can benefit from intervention and treatment with IL5-FU when surgery is not an option due to patient comorbidities. IL5-FU can potentially be used in areas where access to a dermatologist, surgeon, or surgical services is limited.

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Section: Discussionmentioning

confidence: 99%

“…However, it is to be noted that lidocaine was the anesthetic, and trichloroacetic acid (TCA) was subsequently used in the 96-year-old male patient. Although the male patient saw complete regression of the tumor with the use of IL5-FU, the use of TCA may pose a confounding variable in studying the effect of IL5-FU [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Intralesional 5-Fluorouracil in the Treatment of Squamous Cell Carcinoma in an Elderly Patient

McDonald,

Neidenbach

2024

Cureus

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“…Vazquez et al reported a 96 year old patient affected by a localized SCC treated with intralesional injection of 1.5 mL of 5% 5-fluorouracil and then a single layer application of 80% trichloroacetic acid. After 3 weeks, another single application of 80% trichloroacetic acid was sufficient to guarantee the clinical resolution of the lesion [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

Bennardo

Giudice

et al. 2021

Current Oncology

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Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.

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Intralesional 5-fluorouracil for the treatment of squamous cell carcinomas

Maxfield

Shah

Schwartz

et al. 2021

Journal of the American Academy of Dermatology

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A patient with squamous cell carcinoma in-situ successfully treated with intralesional 5-Fluorouracil and topical trichloroacetic acid

Cited by 4 publications

References 12 publications

Intralesional 5-Fluorouracil in the Treatment of Squamous Cell Carcinoma in an Elderly Patient

Intralesional 5-Fluorouracil in the Treatment of Squamous Cell Carcinoma in an Elderly Patient

Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

Intralesional 5-fluorouracil for the treatment of squamous cell carcinomas

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