-The research planed to gather and standard the real world stroke clinical data from clinica to construct a stroke ontology corpus, through refactoring and sharing of data, established a multi-dimensional stroke ontology. And based on stroke diagnosis and treatment process, it integrated the evolution of reasoning mechanism research into the basic tier of theory, designed and implemented a multidimensional ontology the prototype experiment system which has building, reasoning, learning and evolution mechanism. The research results are expected to provide a shared system of concept of stroke to clinical diagnosis and treatment decisions, provide diagnosis and treatment strategy to optimize and design the stroke diagnosis and treatment plan, enhance the accuracy, objectivity and pertinency of diagnosis and treatment level, so as to provide the support of technical method for translating the application and development of medicine, which help to promote scientific, informatization, modernization of traditional Chinese medicine research.