A Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder

Wang, Xinling; Gardner, Wilf; Yu, Shu‐Yan; Serchov, Tsvetan

doi:10.1007/s12035-022-03001-3

Cited by 5 publications

(2 citation statements)

References 139 publications

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“…Furthermore, ICAB increases BDNF expression, a factor capable of providing neuroprotection against anxiety, depression, and memory impairment by increasing phosphorylation of the transcription factor CREB, which is involved in the expression of numerous proteins related to neurogenesis [ 127 , 128 ].…”

Section: Neuroprotective Effects Of Artichokementioning

confidence: 99%

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects. In this context, preventive approaches are gaining increased attention. Recent literature indicates that the consumption of bioactive compounds in the diet can positively influence the organism’s biological functions. Polyphenols, well-known for their health benefits, are widely recognized as valuable compounds in preventing/combating various pathologies related to lifestyle, metabolism, and aging. The C. scolymus belonging to the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Although the inflorescences (capitula) of the artichoke are used for food and culinary purposes, preparations based on artichoke leaves can be used as an active ingredient in herbal medicines. Cynara scolymus shows potential benefits in different domains. Its nutritional value and health benefits make it a promising candidate for improving overall well-being. C. scolymus exhibits anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering neuroprotective properties. Different studies demonstrate that oxidative stress is the leading cause of the onset and progression of major human health disorders such as cardiovascular, neurological, metabolic, and cancer diseases. The large amount of polyphenol found in C. scolymus has an antioxidant activity, enabling it to neutralize free radicals, preventing cellular damage. This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties. As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies. The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.

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Section: Neuroprotective Effects Of Artichokementioning

confidence: 99%

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

View full text Add to dashboard Cite

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“…Interestingly, ICAB is able to inhibit inflammatory response in brain, decreasing the release of pro-inflammatory cytokines, such as TNF-α a n d I L -6. and NF-κBp65 phosphorylation, thus suggesting its excellent antiinflammatory capacity. In addition, ICAB increases the expression levels BDNF, a factor capable of providing neuroprotection against anxiety, depression, and memory impairment by increasing phosphorylation of the transcription factor CREB, implicated in the regulation of genes involved in the expression of numerous proteins related to neurogenesis [121,122].…”

Section: Anti-inflammatory Effects In the Brain And Protective Effect...mentioning

confidence: 99%

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Porro,

Benameur,

Cianciulli

et al. 2023

Preprint

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Several chronic diseases derive from metabolic, genetic, or inflammatory causes and often these causes are interconnected. Pharmacological treatments, although effective, often lead to unpleasant side effects. In this context, preventive approaches are of growing interest. The literature data of recent years support that the dietary intake of bioactive compounds can positively influence the biological functions of an organism. Among the bioactive compounds in the diet, polyphenols are widely recognized for their beneficial effects on health, as useful compounds for preventing/combating a series of pathologies related to lifestyle, metabolism, and aging. The artichoke (Cynara scolymus L.), a member of the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Artichokes are rich in polyphenols (including cynarin), flavonoids and their derivatives, and, for this reason, they have aroused interest in their pharmacological properties. The best-known activity of polyphenols is antioxidant activity. Through it, they help to neutralize free radicals, preventing cellular damage and the subsequent risk of conditions such as cancer, diabetes, and heart disease. Related to the antioxidant action we find the anti-inflammatory activity. This is an important benefit since chronic inflammation is a cause or contributory cause of many chronic diseases. Although many scientific results are of great interest and potential, there are still gaps to be filled. In this review, we report and discuss new insights providing documented evidence regarding the benefits of the artichoke compounds and their possible use to support the pharmacological treatment of pathologies associated with inflammation.

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