A patterned porous polymer film for localized capture of insulin and glucose-responsive release

Abstract

A responsive porous polymer film with insulin loaded efficiently in modified cavities, which is released by a glucose trigger, is prepared.

Polypeptide-participating complex nanoparticles with improved salt-tolerance as excellent candidates for intelligent insulin delivery

“…[3][4][5] Amongst these self-regulated insulin delivery systems, synthetic phenylboronic acid (PBA)-based polymeric materials with high stability have shown more promising applications than glucose oxidase (GOD) and lectin (Con A) based systems. [6][7][8] Until now, a variety of PBA-based glucose-responsive materials particularly in the form of nanoparticles including nanogels (microgels), [9][10][11] micelles, [12][13][14][15] vesicles, [16][17][18][19][20] and mesoporous silica nanoparticles 21,22 have been broadly explored and shown to exhibit effective glucose-responsiveness at physiological pH and reasonable glucose-sensitivity.…”

Self-organized nanocrystal rings formed by microemulsion for selective recognition of proteins and immunoassays

“…Recently, a novel way to synthesize ordered porous structures using microemulsion droplets as template has been proposed. 26,27 Water-phase additives are located at the inner walls of the cavities, which are suitable for further modication of the pore surface. This strategy maintains the advantages of the breath gure method, while QDs pattern can be prepared in one step during the formation of a porous lm.…”

Single Solvent‐Based Film Casting Method for the Production of Porous Polymer Films

“…[6] Fabrication of porous structures from either polymer [7,8] or metal [2,9] or ceramics [10] with diverse pore sizes (from nanoto micrometer range) have been explored extensively. For example, nano, micro, and macroporous polymer films have proven to be suitable for gas separation, [11] biosensing, [3] and drug release applications [12] and metal and ceramic films have been utilized as thermal barrier coatings. [1] Here, we demonstrate a simple, straightforward, inexpensive, and quick method for preparing porous polymer films using a single solvent-based film casting process.…”