This paper develops a quantitative version of de Jong’s central limit theorem for homogeneous sums in a high-dimensional setting. More precisely, under appropriate moment assumptions, we establish an upper bound for the Kolmogorov distance between a multi-dimensional vector of homogeneous sums and a Gaussian vector so that the bound depends polynomially on the logarithm of the dimension and is governed by the fourth cumulants and the maximal influences of the components. As a corollary, we obtain high-dimensional versions of fourth-moment theorems, universality results and Peccati–Tudor-type theorems for homogeneous sums. We also sharpen some existing (quantitative) central limit theorems by applications of our result.