A pectin-based photoactivated bactericide nanosystem for achieving an improved utilization rate, photostability and targeted delivery of hematoporphyrin

Li, Yun; Cai, Zhi; Yin, Yi; Cai, Weiquan; Tao, Shengxiang; Du, Mengting; Zhang, Jingli; Cao, Rui; Li, Yijing; Xu, Wenjin

doi:10.1039/d3tb00300k

Cited by 5 publications

(1 citation statement)

References 55 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with traditional antimicrobial technology, the photodynamic antimicrobial effect has the characteristics of good environmental compatibility and slow resistance development . Photoactivated pesticides (PPs) as PS also have these advantages and are widely used in plant disease management. , However, the disadvantages of easy aggregation, short duration, and low efficiency seriously restrict the efficient application of PPs. , Our previous work has made some attempts to overcome these problems; small-molecule self-assembled nanoparticles based on two photoactivated pesticides (curcumin and berberine) were prepared to exhibit desirable physicochemical properties and better antimicrobial activities than free curcumin and berberine . 5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra( p -toluenesulfonate), a PP, was successfully incorporated in the cage of a variant MOF (HKUST-1) to form nanocapsules for exerting broad-spectrum photodynamic antibacterial activity .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Hollow Mesoporous Copper Sulfide Nanocapsules Loaded with Natural Photoactivated Pesticides for Sustainable Plant Disease Management

Yan,

Hu,

Xiao

et al. 2024

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Photoactivated pesticides (PPs) have photodynamic antimicrobial activities and show good environmental compatibility and slow resistance development. However, the disadvantages of easy aggregation, short duration, and low efficiency seriously restrict the efficient application of PPs. Hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) with unique optical properties show photodynamic antimicrobial activity under light irradiation, which are considered smart drug delivery carriers due to their good water dispersivity and high drug encapsulation surface area. Herein, novel acid-responsive photoactivated pesticide nanocapsules (PPs@HMCuS-CTS NPs) were established by electrostatically coating HMCuS NPs loaded with PPs (curcumin and physcion) with chitosan (CTS). The results showed that the obtained nanocapsules had desirable water dispersivity (PDI0.25) and acid-responsive release properties. The antimicrobial activity of PPs@HMCuS-CTS NPs under light irradiation was more than 1.47 times those of PPs alone and the mixture of PPs and HMCuS NPs due to the synergistic photodynamic antimicrobial activity. Rainfastness, safety assessment, and genotoxicity evaluation demonstrated that the PPs@ HMCuS-CTS NPs deposited more than 1.28 times PPs on plant foliage without any damage to the crop. Therefore, acid-responsive photoactivated pesticide nanocapsules based on HMCuS NPs have the potential to be an efficient and safe pesticide delivery system.

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication of Hollow Mesoporous Copper Sulfide Nanocapsules Loaded with Natural Photoactivated Pesticides for Sustainable Plant Disease Management

Yan,

Hu,

Xiao

et al. 2024

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

GSH‐responsive photoactivated nano‐bactericide based on sulfonated sodium alginate for improving photostability and targeting of methylene blue

Xiao,

Cai,

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Cationic photosensitizers have higher photodynamic antibacterial activity compared with anionic photosensitizers, and with low toxicity and no drug resistance. However, their poor photostability and low utilization rate limit their practical applications. Herein, a new strategy for the construction of a GSH‐responsive antibacterial nanogel system is developed via the electrostatic interaction between methylene blue (MB) and sulfonated sodium alginate (HSSA) to self‐assemble into nanoparticles followed by sulfhydryl cross‐linking in an aqueous solution. The photobleaching of MB can be inhibited due to the self‐aggregation‐caused quenching (ACQ) effect, but the photodynamic activity can be restored by breaking the disulfide‐crosslinking bonds in the nanogel in response to 10 mM GSH. In vitro antibacterial tests prove that the system has antibacterial activity beyond anionic photosensitizers. Antibacterial studies on plants show that the system has targeted antibacterial activity on infected plants and good wettability, retention, and adhesion to plant leaves. Safety evaluation shows that the system has no obvious toxic effect on plants. Therefore, this study provides a new approach to the discovery of novel photodynamic bactericides.

show abstract

A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation

Xu,

Liu,

et al. 2024

Carbohydrate Polymers

View full text Add to dashboard Cite

A pectin-based photoactivated bactericide nanosystem for achieving an improved utilization rate, photostability and targeted delivery of hematoporphyrin

Abstract: Photoactivated pesticides have many advantages, such as high activity, low toxicity, and no drug resistance. However, poor photostability and low utilization rate limit their practical application. Herein, the photosensitizer hematoporphyrin...

Cited by 5 publications

References 55 publications

Fabrication of Hollow Mesoporous Copper Sulfide Nanocapsules Loaded with Natural Photoactivated Pesticides for Sustainable Plant Disease Management

Fabrication of Hollow Mesoporous Copper Sulfide Nanocapsules Loaded with Natural Photoactivated Pesticides for Sustainable Plant Disease Management

GSH‐responsive photoactivated nano‐bactericide based on sulfonated sodium alginate for improving photostability and targeting of methylene blue

A dew-responsive pectin-based herbicide for enhanced photodynamic inactivation

Contact Info

Product

Resources

About