A peculiar case of large primary cutaneous Ewing’s sarcoma of the foot: Case report and review of the literature

Abstract

HighlightsPrimary cutaneous Ewing sarcoma of the foot are rare and usually small tumors.The present case is the largest primary cutaneous Ewing sarcoma of the foot.We treated this tumor with surgery alone.These tumors should be considered into differential diagnosis of superficial lesions.

Primary subcutaneous extraskeletal Ewing’s sarcoma (PNET). A case report and literatura review

“…El sarcoma de Ewing extraóseo / tumores neuro ectodérmicos periféricos (ESS / PNET), son neoplasias raras que representan aproximadamente de 10 a 15% de los sarcomas de tejidos blandos en niños y el 5% de los sarcomas de tejidos blandos en adultos (6). Clínicamente, morfológica y genéticamente ESS/ PNET, comparten muchas características, lo que respalda la hipótesis de que estas dos neoplasias están histogenéticamente relacionadas y son consideradas como parte de la misma familia de tumores (7).…”

“…El carácter menos agresivo del cuadro clínico cutáneo probablemente se produce debido a la ubicación superficial, tumores más pequeños y de fácil acceso, permitiendo la detección a través del examen clínico o por el propio paciente, diagnóstico precoz y resección quirúrgica completa, evitando el inicio de metástasis (10). Cerca de 30-40% de pacientes con ESS/PNET sufren de tumores recurrentes y tienen un muy mal pronóstico, la supervivencia a 5 años después de la recurrencia de estos pacientes fue de a 10-15%, y de 7% para aquellos cuya enfermedad reapareció en 2 años (7).…”

Primary Cutaneous Ewing Sarcoma: Case Report and Review of Literature

“…superficial subcutis They were first described by Angerwall and Enzinger in 1975. The diagnosis is made by aspiration cytology, histochemical stains, immunohistochemistry, electron microscopy, cytogenetics and molecular genetics of translocations [1,3,4]. The differencial diagnosis of ES include primary cutaneous small round cell tumors like Merckel cell carcinoma, eccrine spiradenoma, lymphoma, melanoma, clear cell sarcoma, rhabdomyosarcoma, malignant rhabdoïd tumor, malignant primitive neuroectodermal tumor and poorly differenciated adnexal tumors [5,6].…”

“…It includes also cutaneous metastases from osseous ES, large cell neuroendocrine carcinoma, small cell lung carcinoma and neuroblastoma [1,7]. The ES is composed of small round cells which express the CD99 and molecular study shows a specific chromosomal translocation t(11;22) involving gene EWSR1 in chromosome 22q12 or a fusion or combination between EWSR1 gene and gene of ETS family [1,3,8]. This study is made by FISH or real time polymerase chain reaction (RT-PCR) [8].…”

An unusual case of primary cutaneous Ewing sarcoma in an adult

“…The prognosis of PCES seems better than bone ES . The treatment remains the same for both although some authors suggest that PCES could be treated by surgery alone . Long‐term follow‐up is mandatory to detect metastases which are observed in around 11% of cases …”