A Peculiar Cause of Anaphylaxis: No More steak?

Wolver, Susan; Sun, D.R.; Commins, Scott P.; Schwartz, Lawrence B.

doi:10.1007/s11606-012-2144-z

Cited by 34 publications

(16 citation statements)

References 8 publications

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“…The loss of alpha gal may have made Old World primates resistant to infection, because anti alpha gal antibodies target this foreign epitope on enveloped viruses coming from other mammalian species [64]. Anti alpha gal antibodies can cause severe allergic reactions in humans that eat red meat after immunization by a tick bite [65]. Alpha gal antibodies also prevent organ transplantation from other mammal species – pig organs are rejected partly because they are rich in alpha gal [66].…”

Section: Figurementioning

confidence: 99%

Glycomics: revealing the dynamic ecology and evolution of sugar molecules

Springer

Gagneux

2016

Journal of Proteomics

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Sugars are the most functionally and structurally diverse molecules in the biological world. Glycan structures range from tiny single monosaccharide units to giant chains thousands of units long. Some glycans are branched, their monosaccharides linked together in many different combinations and orientations. Some exist as solitary molecules; others are conjugated to proteins and lipids and alter their collective functional properties. In addition to structural and storage roles, glycan molecules participate in and actively regulate physiological and developmental processes. Glycans also mediate cellular interactions within and between individuals. Their roles in ecology and evolution are pivotal, but not well studied because glycan biochemistry requires different methods than standard molecular biology practice. The properties of glycans are in some ways convenient, and in others challenging. Glycans vary on organismal timescales, and in direct response to physiological and ecological conditions. Their mature structures are physical records of both genetic and environmental influences during maturation. We describe the scope of natural glycan variation and discuss how studying glycans will allow researchers to further integrate the fields of ecology and evolution.

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Section: Figurementioning

confidence: 99%

Glycomics: revealing the dynamic ecology and evolution of sugar molecules

Springer

Gagneux

2016

Journal of Proteomics

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“…The alpha-gal allergy is a newly discovered condition that provides diagnostic challenges (23,24). This novel, severe food allergy to mammalian meat has a highly unusual presentation; unlike most food allergies, there is a delayed reaction between ingestion and symptom onset, usually 3 to 6 hours postconsumption (25).…”

Section: Newly Recognized Food Allergy: Alpha-galmentioning

confidence: 99%

Patients’ Health Information Practices and Perceptions of Provider Knowledge in the Case of the Newly Discovered Alpha-gal Food Allergy

Flaherty

Threats

Kaplan

2018

Journal of Patient Experience

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Background: Alpha-gal food allergy is a life-threatening, newly discovered condition with limited presence in authoritative information sources. Sufferers seeking diagnosis are likely to encounter clinicians unfamiliar with the condition. Objective: To understand information practices of individuals diagnosed with alpha-gal allergy, how they obtained diagnosis, and their perceptions of health-care providers’ awareness of the condition. Methods: Semistructured interviews with open- and closed-ended questions were completed with a chronological systematic sample of 28 adults (11% of alpha-gal clinic patients at the time) diagnosed with alpha-gal allergy and treated at University of North Carolina Allergy and Immunology Clinic. Results: The majority of patients determined they had alpha-gal allergy through nontraditional health information channels. Three-quarters of patients rated their primary care provider as having little to no knowledge. In 25 specialists’ encounters, 23 were rated as having little to no knowledge. Conclusion: With new conditions, information is often available through informal networks before appearing in the vetted medical literature. In this study, social connections were the primary pathway to successful diagnosis. Health practitioners need to develop mechanisms to understand that process.

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“…10,14 Often there is a positive history of a prior tick bite. Bites from A americanum can be severely pruritic, 19 a symptom that can last weeks, 10 making them memorable. Bites might not be recognized as "tick" bites by some patients.…”

Section: Diagnostic Approachmentioning

confidence: 99%