A peculiar lamin in a peculiar mammal: Expression of lamin LIII in platypus (Ornithorhynchus anatinus)

Peter, Annette; Khandekar, Shaunak; Deakin, Janine E.; Stick, Reimer

doi:10.1016/j.ejcb.2015.07.001

Cited by 1 publication

(3 citation statements)

References 52 publications

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“…Its expression is confined to the testis. 31 Third, atypical male germ line-specific lamins have also been found in other tetrapods. They assemble into short rather than long filaments and are thought to alter the properties of the nuclear lamina of spermatogenic cells.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 91%

“…Lamin sequences and their respective genes have been described previously for all major groups of tetrapods. 6,21,31 Three aspects of tetrapod lamin evolution are particularly noteworthy. Marsupials and placental mammals express an additional lamin: lamin C. Lamin C is an alternative splice product of the Lmna gene.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

“…SRA sequences were retrieved via the European nucleotide archive (ENA) (http://www.ebi.ac.uk/ena) and assembled using CLC Genomic Workbench 7.5 software (CLC Bio, A rhus, Denmark) as described. 31 Accession numbers of the proteins, genes, cDNA, and SRA sequences, respectively, are listed in Supplementary Table 5 together with information, how individual lamin sequences were assembled.…”

Section: Sequence Retrieval and Sequence Assemblymentioning

confidence: 99%

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Evolutionary changes in lamin expression in the vertebrate lineage

Stick

Peter

2017

Nucleus

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The nuclear lamina is involved in fundamental nuclear functions and provides mechanical stability to the nucleus. Lamin filaments form a meshwork closely apposed to the inner nuclear membrane and a small fraction of lamins exist in the nuclear interior. Mutations in lamin genes cause severe hereditary diseases, the laminopathies. During vertebrate evolution the lamin protein family has expanded. While most vertebrate genomes contain 4 lamin genes, encoding the lamins A, B1, B2, and LIII, the majority of non-vertebrate genomes harbor only a single lamin gene. We have collected lamin gene and cDNA sequence information for representatives of the major vertebrate lineages. With the help of RNA-seq data we have determined relative lamin expression levels for representative tissues for species of 9 different gnathostome lineages. Here we report that the level of lamin A expression is low in cartilaginous fishes and ancient fishes and increases toward the mammals. Lamin B1 expression shows an inverse tendency to that of lamin A. Possible implications for the change in the lamin A to B ratio is discussed in the light of its role in nuclear mechanics.

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Section: Vertebrate Lamin Proteinsmentioning

confidence: 91%

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

Section: Sequence Retrieval and Sequence Assemblymentioning

confidence: 99%

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