A pediatric case of rhabdomyolysis with acute renal failure due to co-infection with Epstein-Barr virus and Human herpesvirus 6

Attanasi, Marina; Petrosino, Marianna Immacolata; Guidone, Paola; Rapino, Daniele; Comegna, Laura; Rossi, Nadia; Blasetti, Annalisa; Chiarelli, Francesco

doi:10.5114/aoms.2016.61352

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Our case, otherwise healthy, presented with classical triad of rhabdomyolysis, namely myalgia, dark urine and muscle weakness [2]. We evaluated all possible aetiologies including viral infections which are one of the common causes for rhabdomyolysis in children [6,16].…”

Section: Discussionmentioning

confidence: 99%

A Rare Pediatric Case of Severe Rhabdomyolysis Owing to Dual Infection

et al. 2021

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Aim We aimed to report a severe and rare pediatric rhabdomyolysis case associated with a dual viral infection. Case A 13 year-old, healthy girl presented with the complaints of fever, abdominal pain, weakness and dark-colored urine. She was diagnosed with rhabdomyolysis based on clinical signs and laboratory findings. The diagnosis was confirmed by serological tests and real-time polymerase chain reaction for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), respectively. Other potential genetic, metabolic and infectious causes were evaluated meticulously but no evidence was found. This case is also important as it is the first reported case to our knowledge on rhabdomyolysis associated with EBV and CMV co-infection in children. Conclusion The presented case experienced tetraplegia due to the severe muscular damage and muscle power returned to normal range after 3 months. This suggests that EBV and CMV may have exert synergistic effects leading to more severe inflammation and degeneration.

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Section: Discussionmentioning

confidence: 99%

A Rare Pediatric Case of Severe Rhabdomyolysis Owing to Dual Infection

et al. 2021

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“…Serum CK levels exceeding five times the upper limit of normal are commonly used for diagnosing rhabdomyolysis (8). In rhabdomyolysis secondary to viral myositis, the serum CK level usually peaks at 1-5 days (10,11).…”

Section: Discussionmentioning

confidence: 99%

“…There is a lack of guidelines for the best treatment in children with rhabdomyolysis (8,10). Management of acute rhabdomyolysis involves hydration and alkalinization of the urine in order to prevent development of AKI, monitoring for electrolyte imbalance, correction of metabolic acidosis, and management of other complications.…”

Section: Discussionmentioning

confidence: 99%

TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review.

Kheireldin¹,

Imdad

Ostwani³

2020

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We report a unique case of prolonged acute rhabdomyolysis in a 2-year-old male with known TANGO-2 mutation with delayed peak in creatinine kinase levels secondary to human metapneumovirus infection. Creatinine kinase peaked at 424,760 U/l on day 9 of hospitalization. Resolution of rhabdomyolysis was achieved using aggressive management with intravenous fluids with optimal urine output and no kidney injury. TANGO-2 patients may develop severe and prolonged rhabdomyolysis with a delayed peak suggesting the need for prolonged inpatient hospitalization to prevent life-threatening complications.

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“…Potentially all bacterial, viral and fungal infections can lead to RM [111][112][113][114]. Particularly, viral infections may cause various complications involving skeletal muscle, from non-specific myalgias to severe myositis and RM.…”

Section: Bacterial Viral and Fungal Infectionsmentioning

confidence: 99%

“…Tanaka et al [115] identified the influenza virus as an implicated agent in nearly 33% of known virus-induced RM. RM has been described in infections from Staphylococcus aureus, Mycoplasma pneumoniae, tuberculosis, tetanus, Salmonella, Brucella, Legionella and others [116][117][118][119][120][121][122]. Infectious conditions destroy muscle tissue by toxin production or direct bacterial invasion.…”

Section: Bacterial Viral and Fungal Infectionsmentioning

confidence: 99%

Non-traumatic and non-drug-induced rhabdomyolysis

Kolovou

Cokkinos

Bilianou

et al. 2019

Arch Med Sci Atheroscler Dis

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Rhabdomyolysis (RM), a fortunately rare disease of the striated muscle cells, is a complication of non-traumatic (congenital (glycogen storage disease, discrete mitochondrial myopathies and various muscular dystrophies) or acquired (alcoholic myopathy, systemic diseases, arterial occlusion, viral illness or bacterial sepsis)) and traumatic conditions. Additionally, RM can occur in some individuals under specific circumstances such as toxic substance use and illicit drug abuse. Lipid-lowering drugs in particular are capable of causing RM. This comprehensive review will focus on non-traumatic and nondrug-induced RM. Moreover, the pathology of RM, its clinical manifestation and biochemical effects, and finally its management will be discussed.

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A pediatric case of rhabdomyolysis with acute renal failure due to co-infection with Epstein-Barr virus and Human herpesvirus 6

Cited by 5 publications

References 8 publications

A Rare Pediatric Case of Severe Rhabdomyolysis Owing to Dual Infection

A Rare Pediatric Case of Severe Rhabdomyolysis Owing to Dual Infection

TANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review.

Non-traumatic and non-drug-induced rhabdomyolysis

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