A pediatric case of selective fixed drug eruption to amoxicillin

Desquamating Nonpigmenting Fixed Drug Eruption With Onycholysis due to Amoxicillin in a Child: Cross-reactivity Study

“…The drugs that most frequently cause FDE are analgesics, antimalarials, barbiturates, and antibiotics, including amoxicillin [2,3]. Diagnosis of FDE is based on skin tests and drug challenge tests (DCTs) [4]. There are rare clinical variants that include nonpigmenting FDE (NPFDE), generalized FDE, and other atypical presentations.…”

“…We performed a DCT with amoxicillin 750 mg every 8 hours for 7 days. The first dose was administered in our department at 60-minute intervals (1/100, 1/10, full dose) [4], and the patient remained under medical surveillance for 2 hours. The remaining doses were taken at home.…”

“…Papillon-Lefèvre syndrome (PLS, OMIM 245000) is a rare autosomal recessive disorder caused by mutations in the CTSC gene, which is located at 11q14.2 and encodes the enzyme cathepsin C [1]. Cathepsin C activates proinflammatory proteases (eg, NE, PR3, CatG, NSP4, chymases, tryptases, and granzymes), regulates the function of immune cells [2][3][4], and controls the formation of the corneocyte envelope.…”