A Perinatal Palatable High‐Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

Oliveira, Tchana Weyll Souza de; Leandro, Carol Góis; Deiró, Tereza Cristina Bomfim de Jesus; Perez, G. S.; Silva, Darlene da França; Druzian, Janice Izabel; Couto, Ricardo David; Barreto-Medeiros, Jairza Maria

doi:10.1007/s11745-011-3604-7

Cited by 20 publications

(16 citation statements)

References 21 publications

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“…In our previous studies it was shown that malnutrition during pregnancy and lactation can promote lasting effects on the offspring (Barreto-Medeiros et al, 2007;Melo et al, 2011). We also found in previous studies that maternal intake of high fat diet, promoting hypercholesterolemia (Oliveira et al, 2011;Perez et al, 2015), increased visceral fat and hepatic steatosis in rats in adulthood (Perez et al, 2015).…”

Section: Introductionsupporting

confidence: 56%

“…In a previously study, Oliveira et al (2011) showed that this high fat diet has 23% of fat and 41.71% of these lipids are saturated fatty acids, more than twice that found in the control diet (19.17%). According to Tinoco et al (2007), the milk fatty acid profile of mothers who consume a high fat diet resembles the profile of maternal diet.…”

Section: Discussionmentioning

confidence: 77%

“…The high-fat diet consisted of a mixture of hypercaloric foods, including the commercial diet (Nuvilab  ), roasted peanuts, milk chocolate and biscuits, containing 17.0% protein, 46.0% carbohydrates, 23% fat, corresponding to 4.5 kcal/g (Oliveira et al, 2011). The rats kept the consumption of diets throughout the period of pregnancy and lactation.…”

Section: Dietsmentioning

confidence: 99%

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Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats

et al. 2018

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Aim: Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. Methods: Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid). The weight of the animals was measured on alternate days until the 22nd day of life, when collected visceral adipose tissue and blood were collected for biochemical analysis. For statistical analysis the Student t test, Sidak´s teste and two way ANOVA was used, with p <0.05. Results: the test group showed differences in weight gain, visceral adipose tissue and higher cholesterol. Conclusion: a maternal exposure to a high-fat diet during pregnancy and lactation can promote changes in weight gain, hypercholesterolemia and an increase in adipose tissue in neonatal rats.Keywords: high fat diet, neonatal rats, cholesterol, visceral adipose tissue. Efeitos do consumo materno de dieta hiperlipídica durante a gestação e lactação no colesterol total e tecido adiposo de ratos neonatos ResumoObjetivo: A obesidade durante a gestação é um dos fatores de risco mais estabelecidos para uma programação negativa em longo prazo. O objetivo do presente estudo foi investigar os efeitos do consumo materno de uma dieta hiperlipídica durante a gestação e lactação no aumento do peso, do tecido adiposo visceral e colesterolemia em ratos neonatos. Métodos: Ratos Wistar foram divididos em dois grupos de acordo com a dieta da mãe durante a gestação e lactação: grupo controle (GC, n=12) composto por filhotes de ratas alimentadas com uma dieta padrão (lipídios 4%) e o grupo teste (GT, n=12) composto de filhotes de ratas alimentadas com dieta hiperlipídica (lipídios 23%). O peso dos animais foi aferido em dias alternados até o 22° dia de vida, quando foi coletado sangue para análises bioquímicas. Para a análise estatística utilizou-se os seguintes testes: two way ANOVA, teste de Sidak e teste t de Student, com p< 0,05. Resultados: O grupo teste mostrou diferença no ganho de peso, no tecido adiposo visceral e nos níveis de colesterol. Conclusão: Uma exposição materna a uma dieta hiperlipídica durante a gestação e lactação pode promover maior ganho ponderal, hipercolesterolemia e um aumento do tecido adiposo em ratos neonatos.Palavras-chave: dieta hiperlipídica, ratos neonatos, colesterol, tecido adiposo visceral.

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Section: Introductionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 77%

Section: Dietsmentioning

confidence: 99%

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Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats

et al. 2018

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“…Animal models provide strong evidence that perinatal maternal HFDs have an enduring impact on numerous aspects of the offspring's physiology and behavior, including a greater likelihood of developing mental health disorders (Sullivan et al, 2010(Sullivan et al, , 2012Peleg-Raibstein et al, 2012). Several factors are associated with maternal exposure to HFDs during the critical period of the progeny's brain development, such as inflammation (Das, 2001;Bilbo and Tsang, 2010), hypercholesterolemia (Oliveira et al, 2011), lipotoxicity (Sullivan et al, 2010(Sullivan et al, , 2012, hyperglycemia and insulin resistance (Ashino et al, 2012). This set of variables that are associated with maternal HFD can affect the neurodevelopment of the offspring (Soares et al, 2009, Santillán et al, 2010 and are associated with increased risks for mental health disorders, including anxiety, depression and aggressive behavior (Raygada et al, 1998;Sullivan et al, 2010;Peleg-Raibstein et al, 2012), attention deficit hyperactivity disorder (ADHD) (Ray et al, 2009), and autism spectrum disorders (ASD) (Ashwood et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Delayed physical and neurobehavioral development and increased aggressive and depression‐like behaviors in the rat offspring of dams fed a high‐fat diet

Giriko

Andreoli

Mennitti

et al. 2013

Intl J of Devlp Neuroscience

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Early maternal exposure to a high-fat diet (HFD) may influence the brain development of rat offspring and consequently affect physiology and behavior. Thus, in the present study, we investigated the somatic, physical, sensory-motor and neurobehavioral development of the offspring of dams fed an HFD (52% calories from fat, mainly saturated) and the offspring of dams fed a control diet (CD - 14.7% fat) during lactation from the 1st to the 21st postnatal day (P). Maternal body weights were evaluated during lactation. In the progeny, somatic (body weight, head and lengths axes) and physical (ear unfolding, auditory conduit opening, eruption of the incisors and eye opening) development and the consolidation of reflex responses (palm grasp, righting, vibrissa placing, cliff avoidance, negative geotaxis, auditory startle response and free-fall righting) were determined during suckling. Depressive and aggressive behaviors were tested with the forced swimming test (FST) and the "foot-shock" test on days 60 and 110, respectively. The open field test was used to assess motor function. Compared to controls, the HFD-pups exhibited decreases in body weight (P7-P21) and body length (P4-P18), but by days P71 and P95, these pups were overweight. All indicators of physical maturation and the consolidation of the following reflexes, vibrissa placing, auditory startle responses, free-fall righting and negative geotaxis, were delayed in HFD-progeny. In addition, the pups from HFD dam rats also exhibited reduced swimming and climbing times in the FST and increased aggressive behavior. No changes in locomotion were observed. These findings show developmental and neurobehavioral changes in the rat offspring of dams fed the HFD during lactation and suggest possible disruption of physical and sensory-motor maturation and increased susceptibility to depressive and aggressive-like behavior.

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“…Pups from female rats fed HFD during pregnancy and suckling had low birth weight and reduced plasma leptin in PND 2, but became obese and showed increased plasma leptin in adulthood 23 . Moreover, adult offspring from mothers fed HFD (during the same periods) showed hypertension, hypercholesterolemia, hyperphagia, overweight, increased visceral fat, liver weight, blood glucose and triglycerides [7][8][9][10][11] . These abnormalities could be associa ted with alterations of hypothalamic development.…”

mentioning

confidence: 99%

Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring

Mendes‐da‐Silva

Giriko

Mennitti

et al. 2014

Arq. Neuro-Psiquiatr.

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The increasing prevalence of overweight and obesity is a global public health problem that affects both sexes and all age groups, especially women in reproductive age 1 . Currently 65% of the population in the world lives in countries in which obesity causes more deaths than malnutrition 2 . Moreover, the induced-high fat diet (HFD) maternal obesity has risen dramatically over the past 20 years, by nearly 42% in African-Americans and 29% in Caucasians 3 . Within this context, fetuses and newborns are increasingly exposed to maternal HFD which may cause problems in growth and brain deve lopment 4 . However, few stu dies ha ve investigated the effects of maternal HFD on the brain development of the offspring 5,6, particularly isolating or separating the periods of pregnancy and lactation. On the other hand, most studies have evalua ted the effects of maternal obesity or HFD intake along gestation and lactation, hindering the identification of AbstrAct:The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.Keywords: high fat diet, pregnancy, lactation, somatic growth, reflex ontogeny, offspring. resuMo:A exposição materna a dieta rica em gordura (DRG) durante a gravidez e a amamentação tem sido considerada um importante indutor de alterações da programação normal da prole, em animais e humanos, e pode atrapalhar o desenvolvimento do cérebro. No presente estudo, investigamos o desenvolvimento somático e sensório-motor da prole de ratas alimentadas com uma DRG, em comparação com ratas alimentadas com uma dieta controle, durante a gravidez ou lactação. Foram avaliados indicadores de crescimento corporal, maturação física e ontogênese de reflexos. A prole de ratas alimentadas com DRG mostrou redução de peso e crescimento do corpo, atraso da maturação física e maturação tardia de reflexos fisiológicos, tais como colocação pelas vibrissas, resposta ao susto e reação de aceleração. Nossos resultados sugerem que DRG materna durante a gravidez ou lactação modifica desenvolvimento somático e neurológico da prole, possivelmente aumentando o risco para distúrbios neuroendócrinos e neuropsiquiátricos mais tarde na vida.Palavras-chave: ...

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A Perinatal Palatable High‐Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

Cited by 20 publications

References 21 publications

Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats

Effects of maternal high fat intake during pregnancy and lactation on total cholesterol and adipose tissue in neonatal rats

Delayed physical and neurobehavioral development and increased aggressive and depression‐like behaviors in the rat offspring of dams fed a high‐fat diet

Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring

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