A PERKy way to make mitochondrial cristae

Cannon, Barbara; Nedergaard, Jan

doi:10.1016/j.tem.2021.04.003

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…The PERK arm of the unfolded protein response (UPR) has emerged as a prominent stress‐responsive signaling pathway involved in regulating mitochondria during ER stress (Rainbolt et al , 2014 ; Quintana‐Cabrera & Soriano, 2019 ; Cannon & Nedergaard, 2021 ; Almeida et al , 2022 ). PERK is an ER transmembrane protein that is activated in response to ER stress through a mechanism involving oligomerization and autophosphorylation of its cytosolic kinase domain (Fig 1A ; Walter & Ron, 2011 ; Gardner et al , 2013 ; Hetz & Papa, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

et al. 2023

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Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are linked in the onset and pathogenesis of numerous diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria during ER stress. The PERK signaling arm of the unfolded protein response (UPR) has emerged as a prominent ER stress-responsive signaling pathway that regulates diverse aspects of mitochondrial biology. Here, we show that PERK activity promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA) to induce protective mitochondrial elongation during acute ER stress. We find that PERK activity is required for ER stress-dependent increases in both cellular PA and YME1L-dependent degradation of the intramitochondrial PA transporter PRELID1. These two processes lead to the accumulation of PA on the outer mitochondrial membrane where it can induce mitochondrial elongation by inhibiting mitochondrial fission. Our results establish a new role for PERK in the adaptive remodeling of mitochondrial phospholipids and demonstrate that PERK-dependent PA regulation adapts organellar shape in response to ER stress.

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Section: Introductionmentioning

confidence: 99%

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

et al. 2023

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“…The PERK arm of the unfolded protein response (UPR) has emerged as a prominent stress-responsive signaling pathway involved in regulating mitochondria during ER stress. [17][18][19] PERK is an ER transmembrane protein that is activated in response to ER stress through a mechanism involving oligomerization and autophosphorylation of its cytosolic kinase domain (Fig. 1A).…”

Section: Introductionmentioning

confidence: 99%

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

Perea

Cole

Lebeau

et al. 2022

Preprint

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Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are linked in the onset and pathogenesis of numerous diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria during ER stress. The PERK signaling arm of the unfolded protein response (UPR) has emerged as a prominent ER stress-responsive signaling pathway that regulates diverse aspects of mitochondrial biology. Here, we show that PERK activity also promotes adaptive remodeling of mitochondrial membrane phosphatidic acid (PA) to induce protective mitochondrial elongation during ER stress. We find that PERK activity is required for ER stress-dependent increases in both cellular PA and YME1L-dependent degradation of the intramitochondrial PA transporter PRELID1. Together, these processes lead to the accumulation of PA on the outer mitochondrial membrane where it induces mitochondrial elongation by inhibiting mitochondrial fission. Our results establish a new role for PERK in the adaptive remodeling of mitochondrial phospholipids and demonstrate that PERK-dependent PA regulation functions to adapt organellar shape in response to ER stress.

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A Comprehensive Review of Pathophysiological Link Between Non-alcoholic Fatty Liver Disease, Insulin Resistance, and Metabolic Syndrome

Januario,

Barakat,

Rajsundar

et al. 2024

Cureus

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A PERKy way to make mitochondrial cristae

Cited by 3 publications

References 8 publications

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

A Comprehensive Review of Pathophysiological Link Between Non-alcoholic Fatty Liver Disease, Insulin Resistance, and Metabolic Syndrome

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