A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg

Higashida, Haruhiro

doi:10.1016/j.neuint.2012.02.030

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Acetylcholine Release By Mediatophore1

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2016

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“…Fisher et al [13] noticed that fibroblasts genetically modified to express choline acetyltransferase (ChAT) became able to release the transmitter by A23187 [26,27]. Some of other cell lines such as NG108-15 cells expressed voltage-dependent calcium channels that can be activated after depolarization [24,25], so that Ca 2+ dependent ACh release was elicited by electrical stimulation [26].…”

Section: Acetylcholine Release By Mediatophorementioning

confidence: 99%

Neurotransmitter release: vacuolar ATPase V0 sector c-subunits in possible gene or cell therapies for Parkinson’s, Alzheimer’s, and psychiatric diseases

et al. 2016

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Gene therapy or cell transplantation therapy has made great progress in recent years. We overview mediatophore as a potential medical usage for gene and transplantation therapies in the nervous system. The 16-kDa proteolipid mediatophore was shown to mediate the secretion of acetylcholine in a Ca 2+ -dependent manner. Mediatophore is known to be identical to the transmembrane c-subunit of the V0 sector of the vacuolar proton ATPase (ATP6V0C).Recent development of structural understandings reveals that ATP6V0C is not a simple pore-forming stalk enable to permeate transmitters.Therefore, it is time to review this topic revisited from the recent knowledge on ATPase.

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