A personalized approach to interventional treatment of tricuspid regurgitation: experiences from an acute animal study

Abstract

We demonstrated the feasibility in principle of a personalized interventional treatment for tricuspid regurgitation using a braided stent, based on individual cardiac imaging, with anchoring forces mainly exerted on the venae cavae and on the inner surface of the right atrium. The design process of this device is a good indicator of the growing potential of an imaging-based personalized simulation and production approach for the treatment of tricuspid valve disease.

Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology

“…Beyond a surgical guide for hard tissue ( 30 ), a surgical guide with flexible material could be used in partial carcinectomy of soft organs. Regarding implantable devices, a recent study showed that 3DP-based personalized stents could be used for tricuspid regurgitation ( 51 ). In addition, a patient-specific flexible implant for filling a dead zone in the lung after pneumonectomy with a nonmedical-grade silicon material was developed.…”

“…Post-mortem autopsy (H, I) and CT fluoroscopy (J) revealed accurate positioning of valve prostheses. Adapted from Amerini et al Interact Cardiovasc Thorac Surg 2014;19:414-418, with permission of Oxford University Press ( 51 ).…”

“…Beyond hard tissue applications, customized implants created using 3DP have recently been used in the interventional field. Amerini et al ( 51 ) demonstrated the feasibility of a personalized interventional treatment for tricuspid regurgitation using a braided stent in an animal study. Using cardiac CT data, a 3D reconstructed model of the right-sided cardiac cavities of a pig was obtained (OsiriX® Imaging Software; Pixmeo, Switzerland).…”

Development of a Transcatheter Tricuspid Valve Prosthesis Through Steps of Iterative Optimization and Finite Element Analysis

“…gave an overview about some novel percutaneous approaches for the tricuspid valve implantation found in literature . Some devices designed for the orthotopic position reached the state of in vivo animal trials . Lauten et al.…”

“…Pott et al gave an overview about some novel percutaneous approaches for the tricuspid valve implantation found in literature (9). Some devices designed for the orthotopic position reached the state of in vivo animal trials (10)(11)(12)(13). Lauten et al reported two cases of patients who were treated with their device in heterotopic position inside the inferior vena cava (IVC) (14) and inside the inferior and superior vena cava (SVC) (15).…”