2024
DOI: 10.1002/pst.2417
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A Personalized Dose‐Finding Algorithm Based on Adaptive Gaussian Process Regression

Yeonhee Park,
Won Chang

Abstract: Dose‐finding studies play a crucial role in drug development by identifying the optimal dose(s) for later studies while considering tolerability. This not only saves time and effort in proceeding with Phase III trials but also improves efficacy. In an era of precision medicine, it is not ideal to assume patient homogeneity in dose‐finding studies as patients may respond differently to the drug. To address this, we propose a personalized dose‐finding algorithm that assigns patients to individualized optimal bio… Show more

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