A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments

Petta, Dalila; D'Arrigo, Daniele; Salehi, Shima; Talò, Giuseppe; Bonetti, Lorenzo; Vanoni, Marco; Deabate, Luca; De Nardo, Luigi; Dubini, Gabriele; Candrian, Christian; Moretti, Matteo; Lopa, Silvia; Arrigoni, Chiara

doi:10.1016/j.mtbio.2024.101072

Materials Today Bio

2024

DOI: 10.1016/j.mtbio.2024.101072

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A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments

Dalila Petta,

Daniele D'Arrigo,

Shima Salehi

et al.

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Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

Pang,

Chen,

Zhan

et al. 2024

Adv Healthcare Materials

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Osteoarthritis (OA) represents a common degenerative joint disorder marked by progressive cartilage degradation, necessitating innovative therapeutic approaches beyond symptom management. Here, this study introduces a novel strategy leveraging the regenerative capabilities of mesenchymal stem cells (MSCs) by utilizing a bioactive extracellular matrix (ECM) derived from IFN‐γ‐stimulated MSCs, encapsulated within aldehyde‐ and methacrylic anhydride‐modified hyaluronic acid hydrogel microspheres (AH). This engineered scaffold effectively mimics the native cartilage microenvironment, promoting targeted adhesion and retention at damaged sites via spontaneous Schiff base reactions. Notably, the IFN‐γ‐ECM@AH microspheres facilitate the localized release of key chemokines, such as CXCL12, enhancing endogenous stem cell recruitment, and bioactive factors (e.g., TGF‐βI and TGF‐β3) to drive chondrogenic differentiation. Additionally, the scaffold possesses binding sites for cellular integrins, further augmenting the regenerative potential of stem cells. Collectively, the approach presents a dual‐action mechanism that supports efficient cartilage repair and regeneration, positioning this engineered microenvironment as a promising therapeutic avenue for OA and potentially other degenerative conditions.

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Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

Pang,

Chen,

Zhan

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments

Cited by 1 publication

References 55 publications

Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

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