A perspective from experimental studies of burning mouth syndrome

Imamura, Yoshiki; Okada-Ogawa, Akiko; Noma, Noboru; Shinozaki, Takahiro; Watanabe, Kosuke; Kohashi, Ryutaro; Shinoda, Masamichi; Wada, Akihiko; Abe, Osamu; Iwata, Koichi

doi:10.2334/josnusd.19-0459

Cited by 14 publications

(14 citation statements)

References 83 publications

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“…De Kruijf et al reported a significant association between years after menopause and cold and warmth sensitivity thresholds in patients with chronic pain [17]. In a previous study, we found an association between somatosensory dysfunction and disease duration in patients with BMS [14,18].…”

supporting

confidence: 48%

Differences in Somatosensory Function During Premenopause and Early and Late Postmenopause in Patients With Burning Mouth Syndrome

Ozasa¹,

Noma²,

Watanabe³

et al. 2021

Preprint

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Background: This study aimed to examine the association between somatosensory dysfunction and burning mouth syndrome (BMS) in premenopausal, early postmenopausal, and late postmenopausal patients, using a standardized Quantitative Sensory Testing (QST) protocol, and to determine the predictive value of thermal or mechanical perception by QST for detecting BMS.Methods: The study included 36 female participants with BMS (12 premenopausal, 10 early postmenopausal, and 14 late postmenopausal) and 42 age- and sex- matched healthy volunteers (21 premenopausal, 10 early postmenopausal, and 11 late postmenopausal). Neurophysiological tests were used to evaluate somatosensory dysfunction at the tongue.Results: Z-scores in the late postmenopausal BMS group revealed a gain of function for the cold pain threshold and heat pain threshold (Z=2.08 and 3.38, respectively). In the multiple regression analysis with the Visual Analogue Scale as the dependent variable, the vibration detection threshold predicted severity of burning mouth sensation in the premenopausal group.Conclusions: Late postmenopausal patients with BMS showed an increased response of the tongue to noxious thermal stimuli. This supports the theory that changes in sex hormones may affect trigeminal somatosensory function in particular, during the late postmenopausal stage in patients with BMS.

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supporting

confidence: 48%

Differences in Somatosensory Function During Premenopause and Early and Late Postmenopause in Patients With Burning Mouth Syndrome

Ozasa¹,

Noma²,

Watanabe³

et al. 2021

Preprint

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“…Patients with BMS often complain of pain when eating hot or spicy foods. 2 , 12 Quantitative sensory testing (QST) studies of the pain threshold of patients with BMS have had similar findings. Yilmaz et al.…”

Section: Introductionmentioning

confidence: 85%

“… 15 In a previous study, we found an association between somatosensory dysfunction and disease duration in patients with BMS. 12 , 16 …”

Section: Introductionmentioning

confidence: 99%

Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study

Ozasa

Noma

Young

et al. 2022

Journal of Dental Sciences

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Background/purpose Burning mouth syndrome (BMS) is a chronic condition presenting as intraoral burning or dysesthesia, with a high preponderance in menopausal women. This study aimed to examine the association between somatosensory dysfunction and BMS in premenopausal, early postmenopausal, and late postmenopausal patients, using a standardized Quantitative Sensory Testing (QST) protocol, and to determine the predictive value of thermal or mechanical perception by QST for detecting BMS. Materials and methods An observational case–control study was performed with 36 female participants with BMS (12 premenopausal, 10 early postmenopausal, and 14 late postmenopausal) and 42 age- and sex-matched healthy volunteers (21 premenopausal, 10 early postmenopausal, and 11 late postmenopausal). Neurophysiological tests were used to evaluate somatosensory dysfunction at the tongue. Results Z-score in the late postmenopausal BMS group revealed a gain of function for the cold pain threshold and heat pain threshold (Z = 2.08 and 3.38, respectively). In the multiple regression analysis with the Visual Analog Scale as the dependent variable, the vibration detection threshold predicted the severity of burning mouth sensation in the premenopausal group. Conclusion Late postmenopausal patients with BMS showed an increased response of the tongue to noxious thermal stimuli. This supports the theory that changes in sex hormones may affect trigeminal somatosensory function, particularly during the late postmenopausal stage in patients with BMS.

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“…It is important to note that BMS affects taste perception through the interaction between the affected sensory and nearby trigeminal taste fibers, suggesting that it is not exclusively a taste-related pathology. 32 Therefore, treating BMS is more similar to treating chronic pain disorders.…”

Section: Transduction Of Tastementioning

confidence: 99%

Exploring The Tasting System and Clinical Significance of Taste Disorders: A Narrative Review

Giantoro Putri,

Soehartono,

Astiarani

2023

j. urban health res.

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Introduction: This review took an in-depth look at the intricate anatomy of taste buds, unveiling their complex structure and function, delved into the fascinating mechanisms that underlie taste transmission, shedding light on how sensory information is relayed from the taste buds to the brain, enabling us to perceive and differentiate various flavors.Result and Discussions: This narrative review indicates that diverse factors can induce changes in taste buds, ranging from genetic predispositions to external influences such as medications and lifestyle habits. By comprehensively understanding these factors, healthcare professionals and researchers can better identify the root causes of taste problems and devise effective management strategies. Recognizing the clinical significance of taste-related issues is crucial in providing appropriate care and support to individuals experiencing taste disorders.Conclusions: Despite significant advancements in understanding the gustatory function and molecular mechanisms of taste receptor cells, there still needs to be a comprehensive clinical understanding regarding the underlying causes and mechanisms of taste disorders in humans. Keywords: Tasting System - Taste Disorder – Gustatory - Clinical Significance

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A perspective from experimental studies of burning mouth syndrome

Cited by 14 publications

References 83 publications

Differences in Somatosensory Function During Premenopause and Early and Late Postmenopause in Patients With Burning Mouth Syndrome

Differences in Somatosensory Function During Premenopause and Early and Late Postmenopause in Patients With Burning Mouth Syndrome

Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study

Exploring The Tasting System and Clinical Significance of Taste Disorders: A Narrative Review

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