A perspective on sepsis pathogenesis, biomarkers and diagnosis: A concise survey

Kundu, Souvik; Tabassum, Shawana; Kumar, Ratnesh

doi:10.1002/mds3.10089

Cited by 8 publications

(7 citation statements)

References 125 publications

(174 reference statements)

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“…Septic shock and sepsis are major contributors to worldwide mortality. Sepsis is the primary cause of mortality in noncardiac patients in critical care units, as stated by the Centres for Disease Control and Prevention [9] . Critically ill patients frequently experience thiamine deficiency, which can result in lactic acidosis as pyruvate is unable to access the Krebs cycle [10] .…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

Moselhy,

Ghafar,

Alghazaly

et al. 2024

Int. J. Adv. Res. Med.

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Background: Sepsis is a critical medical illness with potentially fatal consequences, prompting the exploration of novel therapeutic interventions aimed at improving patient outcomes. The objective of this study was to assess the influence of administering thiamine and intravenous vitamin C together with hydrocortisone on the prognosis of septic patients in the intensive care unit (ICU). Methods: The current research encompassed 60 patients with sepsis or septic shock into two equal group: the treatment group received intravenous (IV) hydrocortisone, vitamin C and thiamine plus the ordinary medical treatment for sepsis however, the control group received only the ordinary medical. Results: The sepsis related organ failure assessment (SOFA) score was lower in the treatment group compared to the control group, but it didn't reach a significant difference. The mortality rate was lower in the treatment group compared to the control group (46.7% and 63.3%); however, it didn't reach a statistically significant value. With multivariate regression analysis, presence of lower diastolic blood pressure (DBP) and hypertension (HTN) were shown as independent risk factors for mortality. Conclusion:The use of mentioned drugs before did not provide a hastened recovery of septic shock as compared to traditional therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

Moselhy,

Ghafar,

Alghazaly

et al. 2024

Int. J. Adv. Res. Med.

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“…While we have used research quality ELISAs to quantify the biomarker concentrations in this study, we recognize that large-scale bedside application of these biomarkers for clinical care will require rapid, widely available, and validated testing with regulatory approval. Molecular point-of-care testing techniques that aim to detect a combination of biomarkers rapidly using magnetic beads and an electrical detection system or multiplex ELISAs are currently in development ( 51 ), and we propose that TIMP-1 and MMP-3 may warrant further investigation for inclusion on such panels for sepsis. We also acknowledge that we measured a limited number of representative MMP pathway biomarkers based on prior published reports ( 10 , 24 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate With Organ Dysfunction and Mortality in Sepsis

Jones

Reilly

Anderson

et al. 2021

Shock

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Background: Matrix Metalloproteinases (MMP) respond to tissue damage during sepsis. Higher plasma concentrations of MMPs and the tissue-inhibitor of matrix metalloproteinases (TIMP) have been reported in sepsis compared with healthy controls. The objective of this study was to examine if plasma levels of MMP-3, MMP-9, and TIMP-1 associate with mortality and organ dysfunction during sepsis. Methods: We conducted a prospective cohort study of critically ill patients with sepsis adjudicated per Sepsis-3 criteria at a tertiary academic medical center. We measured plasma concentrations of MMP-3, MMP-9, and TIMP-1 on intensive care unit admission. We phenotyped the subjects for shock, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and mortality at 30 days. We used logistic regression to test the associations between the MMPs and TIMP-1 with shock, ARDS, AKI, and mortality. Results: Higher plasma TIMP-1 levels were associated with shock (odds ratio [OR] 1.51 per log increase [95% CI 1.25, 1.83]), ARDS (OR 1.24 [95% CI 1.05, 1.46]), AKI (OR 1.18 [95% CI 1.01, 1.38]), and mortality (OR 1.20 [95% CI 1.05, 1.46]. Higher plasma MMP-3 concentrations were associated with shock (OR 1.40 [95% CI 1.12, 1.75]) and mortality (OR 1.24 [95% CI 1.03, 1.48]) whereas MMP-9 levels were not associated with outcomes. Higher plasma TIMP-1 to MMP-3 ratios were associated with shock (OR 1.41 [95% CI 1.15, 1.72], P = 0.02). Conclusion: Elevated plasma concentrations of TIMP-1 associate with organ dysfunction and mortality in sepsis. Higher plasma levels of MMP-3 associate with shock and mortality. Plasma MMP and TIMP-1 may warrant further investigation as emerging sepsis theragnostic biomarkers.

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“…The primary function of anti-inflammatory cytokines is to mediate/suppress the inflammation. A delicate balance between the pro-and antiinflammatory responses is crucial to the orderly and timely healing of wounds (Kolaczkowska and Kubes, 2013;Mantovani et al, 2013;Novak and Koh, 2013;Wilgus et al, 2013;McLister et al, 2014;Oliveira et al, 2016;McLister et al, 2017;Kundu, et al, 2020). Therefore, it is noteworthy that realtime detection and monitoring of both pro-and antiinflammatory elements of the immune system is essential for the effective management of chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

IoT-Enabled Integrated Smart Wound Sensor for Multiplexed Monitoring of Inflammatory Biomarkers at the Wound Site

Noushin

Hossain

Tabassum

2022

Front. Nanotechnol.

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Chronic wounds that stall at the inflammatory phase of healing may create several life-threatening complications such as tissue damage, septicemia, and organ failures. In order to prevent these adverse clinical outcomes and accelerate the wound healing process, it is crucial to monitor the wound status in real-time so that immediate therapeutic interventions can be implemented. In addition, continuous monitoring of the wound status can prevent drug overdose at the wound site, leading to on-demand and personalized drug delivery. Inflammatory mediators, such as Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are promising indicators for the progression of wound healing and predictors of disease severity. Toward this end, this work reports a flexible wound patch for multiplexed monitoring of IL-6 and IL-10 at the wound site in order to provide real-time feedback on the inflammation phase of the wound. An optimized composition of gold nanoparticles integrated multiwalled carbon nanotube was demonstrated to improve sensor performance substantially. The sensor also exhibited excellent repeatable, reversible, and drift characteristics. A miniaturized Internet-of-things (IoT)-enabled potentiostat was also developed and integrated with the flexible sensor to realize a wearable system. This IoT-enabled wearable device provides a smart and cost-effective solution to improving the existing wound care through continuous, real-time, and in-situ monitoring of multiple wound biomarkers.

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A perspective on sepsis pathogenesis, biomarkers and diagnosis: A concise survey

Cited by 8 publications

References 125 publications

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate With Organ Dysfunction and Mortality in Sepsis

IoT-Enabled Integrated Smart Wound Sensor for Multiplexed Monitoring of Inflammatory Biomarkers at the Wound Site

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