A Perspective on the Mobilization, Localization and Delivery of Molecules in the Crowded Bacterial Cytoplasm

Abstract

It has been assumed that diffusion of molecules in the bacterial cytoplasm is the mechanism that moves molecules in the absence of cytoplasmic streaming. However, is there an undiscovered mechanism present that mobilizes cytoplasm and its molecular contents, and delivers tRNAs to specific ribosomes at specific bacterial cytoplasmic locations? Mobilization of specific tRNA (and also mRNA transcripts and ribosomes) and cell division proteins to specific intracellular locations may suggest that instructions and/or mechanism(s) are needed. The alternative is that molecular crowding in the cytoplasm is sufficient for gentle contact between mRNA, ribosomes and tRNA. Or is it plausible that the bacterial cytoplasm (and its contents) are mobilized with the outcome being more gentle collisions between molecules than by a diffusion only mechanism? One hypothesis is that cytoplasmic and molecule mobilization and spatial organization are possibly driven by the photons in thermal infrared (IR) radiation and generation of exclusion zone (EZ) water in the cytoplasm.

Diffusion Dynamics of Star-Shaped Macromolecules in Dilute Solutions

“…Polyethylene glycol stars are used for protein delivery . Understanding macromolecular diffusion in a biological cell is important for its various functions, such as the movement of plasmids and transport of amino acids. , Hence, the influence of the shape and size of the polymer chain on its diffusive dynamics in solution is essential. There have been quite a significant number of contributions toward determining the shape of the polymer chain using theory, experiments, and simulations.…”