A perspective on the physical, mechanical and biological specifications of bioinks and the development of functional tissues in 3D bioprinting

Williams, David; Thayer, Patrick; Martínez, Héctor; Gatenholm, Erik; Khademhosseini, Ali

doi:10.1016/j.bprint.2018.02.003

Cited by 117 publications

(82 citation statements)

References 216 publications

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“…The viscosity and surface tension of the printing solution are important to the development of cell-loaded fibers using C-ES. The viscosity of the bioink not only affects the cell-embedding efficiency, but also the printability [23]. Generally, low-viscosity bioinks are advantageous, as higher viscosities result in greater shear stress which can negatively affect the cells [24].…”

Section: Materials Parametersmentioning

confidence: 99%

Cell-Electrospinning and Its Application for Tissue Engineering

Hong

Yeo

Yang

et al. 2019

IJMS

138

121

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Electrospinning has gained great interest in the field of regenerative medicine, due to its fabrication of a native extracellular matrix-mimicking environment. The micro/nanofibers generated through this process provide cell-friendly surroundings which promote cellular activities. Despite these benefits of electrospinning, a process was introduced to overcome the limitations of electrospinning. Cell-electrospinning is based on the basic process of electrospinning for producing viable cells encapsulated in the micro/nanofibers. In this review, the process of cell-electrospinning and the materials used in this process will be discussed. This review will also discuss the applications of cell-electrospun structures in tissue engineering. Finally, the advantages, limitations, and future perspectives will be discussed.

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Section: Materials Parametersmentioning

confidence: 99%

Cell-Electrospinning and Its Application for Tissue Engineering

Hong

Yeo

Yang

et al. 2019

IJMS

138

121

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show abstract

“…In polymer printing, it has been reported that the honeycomb pattern is relatively tough with an increase in infill density (20%, 50%, and 100%) as compared to rectilinear and line patterns [94]. In bio-printing, a well-developed inner structure in 3D tissues construction such as a cross-link pattern is essential to maintain the mechanical properties of the constructs [95]. There are also few reports on designing an internal structure of 3D constructs to modify the textural properties of the printed foods.…”

Section: Materials For 3d Food Printingmentioning

confidence: 99%

How to Formulate for Structure and Texture via Medium of Additive Manufacturing-A Review

Gholamipour‐Shirazi

Kamlow

Norton

et al. 2020

Foods

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Additive manufacturing, which is also known as 3D printing, is an emerging and growing technology. It is providing significant innovations and improvements in many areas such as engineering, production, medicine, and more. 3D food printing is an area of great promise to provide an indulgence or entertaining experience, personalized food product, or specific nutritional needs. This paper reviews the additive manufacturing methods and materials in detail as well as their advantages and disadvantages. After a full discussion of 3D food printing, the reports on edible printed materials are briefly presented and discussed. In the end, the current and future outlook of additive manufacturing in the food industry is shown.

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“…Similar challenges exist as with extrusion bioprinting apply, namely cell damage during and after printing, stability of the printed structures, and print fidelity and resolution. Recent review of inkjet printing and related bioinks can be found here [55][56][57][58].…”

Section: Inkjet Printingmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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A perspective on the physical, mechanical and biological specifications of bioinks and the development of functional tissues in 3D bioprinting

Cited by 117 publications

References 216 publications

Cell-Electrospinning and Its Application for Tissue Engineering

Cell-Electrospinning and Its Application for Tissue Engineering

How to Formulate for Structure and Texture via Medium of Additive Manufacturing-A Review

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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