A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines

Pérez-Martínez, Ana S.; Acevedo-Padilla, Sergio A.; Martínez, Martha Dolores Bibbins; Galván-Alonso, Jenifer; Rosales‐Mendoza, Sergio

doi:10.1016/j.vaccine.2014.10.059

Cited by 22 publications

(11 citation statements)

References 75 publications

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“…Although vaccination is one of the most powerful and cost-competitive achievements, some vaccines may still have certain limitations related to maintenance of the cold chain, downstream processing costs, administration risk, and expensive scalability [13,14,15,16,17]. From these reasons, the use of plant cells as alternative production platforms have received considerable attention in terms of intrinsic safety, scalability, and posttranslational modification of target proteins [17,18].…”

Section: Plant-based Expression System For Vaccine Developmentmentioning

confidence: 99%

“…From these reasons, the use of plant cells as alternative production platforms have received considerable attention in terms of intrinsic safety, scalability, and posttranslational modification of target proteins [17,18]. Plant systems can be scaled up quickly to generate large quantities of the protein product, are not susceptible to contamination with known human or mammalian pathogens and are resistant to enzymatic digestion in the gastrointestinal tract.…”

Section: Plant-based Expression System For Vaccine Developmentmentioning

confidence: 99%

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The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Joung

Park

Moon

et al. 2016

IJMS

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Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.

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Section: Plant-based Expression System For Vaccine Developmentmentioning

confidence: 99%

Section: Plant-based Expression System For Vaccine Developmentmentioning

confidence: 99%

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Joung

Park

Moon

et al. 2016

IJMS

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“…The Pleurotus spp. of the class basidiomycetes belongs to a group known as “white rot fungi” (Tsujiyama and Ueno, 2013) as they produce a white mycelium and are generally cultivated on non-composted lignocellulosic substrates (Savoie et al, 2007) in which various kinds of Pleurotus are commercially cultivated and have considerable economic value, including P. ostreatus (oyster mushroom), P. eryngii (king oyster or Cardoncello), P. pulmonarius (phenix mushroom), P. djamor (pink oyster mushroom), P. sajor-caju (indian oyster), P. cystidiosus (abalone oyster), P. citrinopieatus (golden oyster mushroom) and P. cornucopiae (Pérez-Martínez et al, 2015, Knop et al, 2015, Zhang et al, 2016). Pleurotus species require a short growth time, compared to other mushrooms.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting mushroom Pleurotus spp.

Bellettini

Fiorda

Maieves

et al. 2019

Saudi Journal of Biological Sciences

338

210

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Pleurotus genus is one of most extensively studied white-rot fungi due to its exceptional ligninolytic properties. It is an edible mushroom and it also has several biological effects, as it contains important bioactive molecules. In basidiomycete fungi, lignocellulolytic enzymes are affected by many typical fermentation factors, such as medium composition, ratio of carbon to nitrogen, pH, temperature, air composition, etc. The survival and multiplication of mushrooms is related to a number of factors, which may act separately or have interactive effects among them. Out that understanding challenges in handling Pleurotus species mushroom requires a fundamental understanding of their physical, chemical, biological and enzymatic properties. This review presents a practical checklist of available intrinsic and extrinsic factors, providing useful synthetic information that may help different users. An in-depth understanding of the technical features is needed for an appropriate and efficient production of Pleurotus spp.

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“…In particular, polysaccharides act as a defense mechanism against invasion by foreign bodies to enhance the natural immune system, including activation of macrophages and natural killer (NK) cells (Figures 2 & 3). The defense mechanism by polysaccharide increases macrophage cytotoxic activity against tumor cells and in the Management of Immunocompromised Patients microorganisms; activates phagocytic activity; increases reactive oxygen species (ROS) and nitric oxide (NO) production, and enhances secretion of cytokines and chemokines, such as tumor necrosis factor (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and IFN-β2 [25,58]. Several years ago, three antitumor agents of polysaccharide nature i.e.…”

Section: Immunotherapy Of Mushroom Polysaccharides From Pleurotus Spementioning

confidence: 99%

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

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Abstract:In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of Bcells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

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A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines

Cited by 22 publications

References 75 publications

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

Factors affecting mushroom Pleurotus spp.

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

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