A Perspective Overview on Hygrophila auriculata

Dhanalakshmi, S.; Harikrishnan, N.; Srinivasan, Naveen; Pandian, P.; Tanisha, B A; Kumar, Manjeet; Lokesh, V; Yuvashri, N; Supriya, S

doi:10.5530/pj.2020.12.237

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…The active chemical constituents present in H. auriculata plants are Apigenin-7-Oglucuronide, apigenin-7-o-glucoside lupeol, betulin, stigmasterol, β-sitosterol, and lupeol. Lupeol maximum content was found in the roots (0.25%), and β-sitosterol top content was found in the leaves (0.069%) 15 . The invitro/in-vivo animal screening proved that lupeol shows potent immunomodulatory activity against the HSV-1 and Acyclovir (ACV) resistant strains 16 .…”

Section: Botanical Descriptionmentioning

confidence: 95%

Analytical Method Development, Validation, and Estimation of Lupeol, Quercetin, Vasicine in Polyherbal Formulations and Selected Plant Species by using UFLC-MS

Jatoth,

Dhanabal,

Kalakotla

et al. 2024

JNR

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Background: Kabusura kudineer (KSK) is a marketed Siddha-based polyherbal formulation, and on the authority of the Govt of India, the Ministry of Ayush recommended Kabusura kudineer in the therapy of COVID-19, and due to its immuno-booster effects. Based on the “Kabusura kudineer” (KSK) formulations, we developed a “Hydaljss08” polyherbal formulation composed of 16 dried crude materials and 03 fresh forms. Both formulations contain active phytopharmaceuticals such as vasicine, quercetin, and lupeol and these are responsible for anti-viral and immunomodulatory effects, which may be due to their synergistic and additive effects. The chemical nature of vasicine is an alkaloid, quercetin is a flavonoid, and lupeol is a pentacyclic triterpenoid. Aim: The current study aims to develop and validate the analytical process for assessing vasicine, quercetin, and lupeol in both dosage forms and in a selected plant species by UFLC-MS. Methods: The ultrafast liquid chromatography study was designed by the columns of Inertsil C8, and Inertsil C18, individually, for vasicine, quercetin, and lupeol respectively. The columns and mobile phase were used as a water C18, 20 mM phosphate buffer pH 2.5: acetonitrile in a combined UFLC method development of vasicine, quercetin, and lupeol. Results: A calibration curve and adequate linearity were recorded for vasicine, quercetin, and lupeol by injecting 20.0-60.0 μg/ml, 50.0-150.0 μg/ml, and 25.0-75.0 μg/ml of marker substances. The LOD, and LOQ of the vasicine, quercetin, and lupeol were found to be 1.19, 3.60, 3.80, 11.51, 1.79, and 5.41 μg/ml, and the Ruggedness value of vasicine, lupeol, and quercetin was found in % RSD 0.4%, 0.1%, and 0.1%. Conclusion: The developed and validated method showed good linearity with a range of correlation coefficients, new, simple, novel, accurate, specificity, precision, robustness, and ruggedness are within the limits.

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Section: Botanical Descriptionmentioning

confidence: 95%

Analytical Method Development, Validation, and Estimation of Lupeol, Quercetin, Vasicine in Polyherbal Formulations and Selected Plant Species by using UFLC-MS

Jatoth,

Dhanabal,

Kalakotla

et al. 2024

JNR

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“…Leaves of this shrub are whorled, linear-lanceolate, with undulating margins. Traditionally, the leaves were used as/in diuretic, jaundice, antibacterial, dropsy, rheumatism, diseases of the urinogenital tract, aphrodisiac, hypnotic, diarrhea, dysentery, urinary calculi, urinary discharge, anti-inflammatory, joint pain, eye diseases, anemia, anuria, cough, stomachic, lumbago, arthritis, gastric disorder and leucorrhea [6] .…”

mentioning

confidence: 99%

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Ekambaram¹,

Santhy²

2022

IJPS

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Hygrophila auriculata is a thorny sub-shrub of the family Acanthaceae. It is a potent medicinal plant in the Indian systems of medicine with various therapeutic uses, from simple management of infections to treatment of diseases. The present study was conducted to investigate the phytochemical and pharmacological properties of the leaves of Hygrophila auriculata. The screening of various phytochemicals was performed using a standard procedure and the characterization was analyzed with spectral studies. The pharmacological investigation includes antioxidant and antimicrobial activities of the extract. Antioxidant activity was carried out using 2, 2-diphenylpicrylhydrazyl free radical scavenging assay and reducing power assay. Antimicrobial activity was done by the agar well diffusion method. The phytochemical screening detected alkaloids, flavonoids, terpenoids, tannins, carbohydrates and saponins. The 2,2-diphenylpicrylhydrazyl antioxidant assay reveals that the extract had a considerable scavenging capacity. It was found that the reducing power of different concentrations of the leaf extract was remarkable. Antimicrobial tests revealed that the leaf extract was active against selected Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) and few fungal species (Aspergillus sp.). These findings disclosed that the Hygrophila auriculata leaves have various phytotherapeutic activities and the compounds identified using the gas chromatography were responsible for the above activities. Thus, it would be helpful to isolate the compounds responsible for the bioactivities in the future for treatment of various ailments.

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Evaluation and efficacy of plant extracts in eradicating medically important mosquitoes: a review

Dass

2024

Toxicol. Environ. Health Sci.

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A Perspective Overview on Hygrophila auriculata

Cited by 6 publications

References 2 publications

Analytical Method Development, Validation, and Estimation of Lupeol, Quercetin, Vasicine in Polyherbal Formulations and Selected Plant Species by using UFLC-MS

Analytical Method Development, Validation, and Estimation of Lupeol, Quercetin, Vasicine in Polyherbal Formulations and Selected Plant Species by using UFLC-MS

Phytochemical Characterization and Assessment of Hygrophila auriculata (Buch. -Ham) Leaves for Antioxidant and Antimicrobial Activity

Evaluation and efficacy of plant extracts in eradicating medically important mosquitoes: a review

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