A pH-activated charge convertible quantum dot as a novel nanocarrier for targeted protein delivery and real-time cancer cell imaging

Zhao, Ting; Fu, Yan; Jang, Moon‐Sun; Sun, Xin; Wu, Tepeng; Lee, Jun Young; Li, Yang; Lee, Sang Soo; Yang, Hong Yu

doi:10.1016/j.msec.2020.111449

Cited by 9 publications

(2 citation statements)

References 57 publications

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“…Currently, most of the pH-responsive luminophores emit in the visible region which can be susceptible to interference in biosensing due to the absorption and autofluorescence from the biological tissues. In addition, pH-driven charge reversal ability has been adopted in a number of drug and gene carriers, especially in antitumor therapies. − However, only a few examples of detection assays involved charge-reversal of probe molecules − and the application of such concept in pH sensing is relatively underexplored.…”

Section: Introductionmentioning

confidence: 99%

Induced Self-Assembly and Disassembly of Alkynylplatinum(II) 2,6-Bis(benzimidazol-2′-yl)pyridine Complexes with Charge Reversal Properties: “Proof-of-Principle” Demonstration of Ratiometric Förster Resonance Energy Transfer Sensing of pH

Chan

Yam

2022

ACS Appl. Mater. Interfaces

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A series of pH-responsive alkynylplatinum(II) 2,6-bis(benzimidazol-2′-yl)pyridine (bzimpy) complexes with charge-reversal properties was synthesized, and the supramolecular assemblies between conjugated polyelectrolyte, PFP-OSO 3 − , and [Pt{bzimpy(TEG) 2 }{C�C−C 6 H 3 −(COOH) 2 -3,5}]Cl (1) have been studied using UV−vis absorption, emission, and resonance light scattering (RLS) spectroscopy. An efficient Forster resonance energy transfer (FRET) from PFP-OSO 3 − donor to the aggregated 1 as acceptor with the aid of Pt(II)•••Pt(II) interactions has been presented, which leads to a growth of triplet metal−metal-toligand charge transfer ( 3 MMLCT) emission in the low-energy red region. The twocomponent PFP-OSO 3 − −1 ensemble was then exploited as a "proof-of-principle" concept strategy for pH sensing by tracking the ratiometric emission changes. With the aid of judicious molecular design on the pH-driven charge-reversal property, the polyelectrolyte-induced self-assembly and the FRET from PFP-OSO 3 − to the platinum(II) aggregates have been modulated. Together with its excellent reversibility and photostability, the extra stability provided by the Pt(II)•••Pt(II) and π−π stacking interactions on top of the electrostatic and hydrophobic interactions existing in polyelectrolye−complex assemblies has led to a selective and sensitive pH sensing assay.

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Section: Introductionmentioning

confidence: 99%

Induced Self-Assembly and Disassembly of Alkynylplatinum(II) 2,6-Bis(benzimidazol-2′-yl)pyridine Complexes with Charge Reversal Properties: “Proof-of-Principle” Demonstration of Ratiometric Förster Resonance Energy Transfer Sensing of pH

Chan

Yam

2022

ACS Appl. Mater. Interfaces

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“…For example, Zhao et al introduced core/multishell CdSe@ZnS/ZnS quantum dots functionalized with multifunctional polypeptide ligands for pH‐responsive protein delivery and cellular imaging. [ 37 ] Also, the integration of semiconductor quantum dots within different hydrogels has been evaluated for fluorescence imaging and biosensing applications. [ 38–40 ] Although semiconductor quantum dots show a stable and considerable fluorescence without photobleaching, their significant toxicity has limited their applications in biomedical imaging.…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dots for Fluorescent Labeling of Gelatin‐Based Shear‐Thinning Hydrogels

Nasrollahi

Nazir

Tavafoghi

et al. 2021

Advanced NanoBiomed Research

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The efficiency of injectable biomaterials as minimally invasive therapeutics significantly relies on biomaterial's characteristics, such as stability, biodegradation rate, and interaction with the host tissue, which requires real‐time tracking of the biomaterials. Fluorescence imaging is considered as a noninvasive technique for monitoring biomaterials; however, the commonly used fluorescent agents are often accompanied by photobleaching and toxicity. Herein, graphene quantum dots (GQDs) are introduced as a biocompatible and stable fluorophore for imaging and noninvasive monitoring of a physically cross‐linked injectable shear‐thinning biomaterial (STB) of gelatin–silicate nanoplatelets. Silicate nanoplatelets and GQDs serve as the physical cross‐linkers of gelatin making electrostatic interaction with gelatin chains. Different STB‐GQDs formulations are assessed in terms of fluorescence intensity, injectability, thermal stability, and cellular biocompatibility. STB‐GQDs with 0.06% GQDs, 6% solid material, and 50% silicate in the solid material show the strongest in vitro fluorescence and the highest thermal stability. In vivo monitoring of STB‐GQDs is also achieved through fluorescent imaging where incorporated GQDs exhibit a robust and stable signal, suggesting their promising applications in long‐term tracking of gelatin‐based STBs.

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Design of Smart Size‐, Surface‐, and Shape‐Switching Nanoparticles to Improve Therapeutic Efficacy

Montague

Pollinzi

et al. 2021

Small

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Multiple biological barriers must be considered in the design of nanomedicines, including prolonged blood circulation, efficient accumulation at the target site, effective penetration into the target tissue, selective uptake of the nanoparticles into target cells, and successful endosomal escape. However, different particle sizes, surface chemistries, and sometimes shapes are required to achieve the desired transport properties at each step of the delivery process. In response, this review highlights recent developments in the design of switchable nanoparticles whose size, surface chemistry, shape, or a combination thereof can be altered as a function of time, a disease‐specific microenvironment, and/or via an externally applied stimulus to enable improved optimization of nanoparticle properties in each step of the delivery process. The practical use of such nanoparticles in chemotherapy, bioimaging, photothermal therapy, and other applications is also discussed.

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A pH-activated charge convertible quantum dot as a novel nanocarrier for targeted protein delivery and real-time cancer cell imaging

Cited by 9 publications

References 57 publications

Induced Self-Assembly and Disassembly of Alkynylplatinum(II) 2,6-Bis(benzimidazol-2′-yl)pyridine Complexes with Charge Reversal Properties: “Proof-of-Principle” Demonstration of Ratiometric Förster Resonance Energy Transfer Sensing of pH

Induced Self-Assembly and Disassembly of Alkynylplatinum(II) 2,6-Bis(benzimidazol-2′-yl)pyridine Complexes with Charge Reversal Properties: “Proof-of-Principle” Demonstration of Ratiometric Förster Resonance Energy Transfer Sensing of pH

Graphene Quantum Dots for Fluorescent Labeling of Gelatin‐Based Shear‐Thinning Hydrogels

Design of Smart Size‐, Surface‐, and Shape‐Switching Nanoparticles to Improve Therapeutic Efficacy

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