A pH-insensitive, ratiometric chemosensor for citrate using europium luminescence

Parker, David; Yu, Junhua

doi:10.1039/b502553b

Cited by 114 publications

(51 citation statements)

References 22 publications

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“…[22] These complexes are widely applied as labels in various luminescence assays both as free dyes bearing a functional group for conjugation and in the form of dye-doped nanoparticles, [22,23] but application in optical sensors and analyte-sensitive probes is comparably rare. [24][25][26][27] For example, luminescent Eu(III) complexes were applied as optical temperature probes, [27][28][29][30][31] pH indicators, [32][33][34][35][36] fluoroionophores for bicarbonate, [37,38] citrate [39] and lactate [40] and as hydrogen peroxide [41] and nitrogen monooxide probes. [42] Several Eu(III) complexes were applied as luminescent oxygen indicators.…”

Section: Introductionmentioning

confidence: 99%

Exceptional Oxygen Sensing Properties of New Blue Light‐Excitable Highly Luminescent Europium(III) and Gadolinium(III) Complexes

Borisov

Fischer

Saf

et al. 2014

Adv Funct Materials

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New europium(III) and gadolinium(III) complexes bearing 8-hydroxyphenalenone antenna combine efficient absorption in the blue part of the spectrum and strong emission in polymers at room temperature. The Eu(III) complexes show characteristic red luminescence whereas the Gd(III) dyes are strongly phosphorescent. The luminescence quantum yields are about 20% for the Eu(III) complexes and 50% for the Gd(III) dyes. In contrast to most state-of-the-art Eu(III) complexes the new dyes are quenched very efficiently by molecular oxygen. The luminescence decay times of the Gd(III) complexes exceed 1 ms which ensures exceptional sensitivity even in polymers of moderate oxygen permeability. These sensors are particularly suitable for trace oxygen sensing and may be good substitutes for Pd(II) porphyrins. The photophysical and sensing properties can be tuned by varying the nature of the fourth ligand. The narrow-band emission of the Eu(III) allows efficient elimination of the background light and autofluorescence and is also very attractive for use e.g. in multi-analyte sensors. The highly photostable indicators incorporated in nanoparticles are promising for imaging applications. Due to the straightforward preparation and low cost of starting materials the new dyes represent a promising alternative to the state-ofthe-art oxygen indicators particularly for such applications as e.g. food packaging.

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Section: Introductionmentioning

confidence: 99%

Exceptional Oxygen Sensing Properties of New Blue Light‐Excitable Highly Luminescent Europium(III) and Gadolinium(III) Complexes

Borisov

Fischer

Saf

et al. 2014

Adv Funct Materials

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“…Indeed, the images obtained in Figure 2 accord with that view. Because of the intrinsic brightness of these Eu probes, the power used in pulsed excitation 50 is only 4 mW (<80 nJ/voxel/acquisition). 38 These experimental conditions are far removed from those used to assess UV damage to tissues and cells, where continuous light exposure persists for several seconds or minutes, and the impact is a steep function of the excitation wavelength, with much less damage occurring 55 above 340 nm.…”

Section: Stability To Photobleaching and Pulsed Excitation At 355 Nmmentioning

confidence: 99%

EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging

Lamarque²,

et al. 2014

Self Cite

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Nine very bright europium(III) complexes with different macrocyclic ligands have been prepared that exhibit excellent cell uptake behaviour and distinctive sub-cellular localisation profiles, allowing the use of fluorescence microscopy and time-gated spectral imaging to track their fate in cellulo. Their use as cellular imaging stains is described for the selective illumination of mitochondria, lysosomes or the endoplasmic reticulum of various mammalian cell types.

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“…The luminescence of the Eu 3+ chelate 10 is efficiently quenched by Cu 2+ ions in aqueous medium [30]. In contrast to the receptors shown above, chelating structures with polydentate ligands can also be applied for determination of analytes that act as secondary ligands for the lanthanide center, e.g., hydrogen carbonate, acetate, lactate, citrate, or amino acids [31][32][33], and form thereby ternary complexes. Heptadentate ligands based on cyclen leave two binding sites unallocated, which can be occupied by additional small ligands and cause a luminescence response.…”

Section: Complexes With Macrocyclic and Polydentate Ligandsmentioning

confidence: 95%

Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

Spangler

Schäferling

2010

Lanthanide Luminescence

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Luminescent lanthanide complexes (LLCs) are versatile probes for the determination of a variety of analytes such as metal ions, anions, hydrogen peroxide, ATP, pH, or oxygen. Antenna chromophores have been introduced as ligands for sensitizing lanthanide emission. The ligand system or the lanthanide ion can act as receptors for reversible binding of analytes. Thus, the response of luminescence emission can occur via ligand or metal-centered processes, which will both be discussed. LLCs, particularly Eu 3+ and Tb 3+ complexes, have been incorporated in solid state matrices, e.g., polymer hydrogels or silica to obtain optical sensor layers. A selection of such sensitive materials will be outlined, including sensors for the analytically relevant parameters oxygen, pH, hydrogen peroxide, humidity, and temperature.

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A pH-insensitive, ratiometric chemosensor for citrate using europium luminescence

Abstract: A chemoselective sensor for the citrate anion has been devised, based on a new europium complex that offers ratiometric analysis of the long-lived emission.

Cited by 114 publications

References 22 publications

Exceptional Oxygen Sensing Properties of New Blue Light‐Excitable Highly Luminescent Europium(III) and Gadolinium(III) Complexes

Exceptional Oxygen Sensing Properties of New Blue Light‐Excitable Highly Luminescent Europium(III) and Gadolinium(III) Complexes

EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging

Luminescent Chemical and Physical Sensors Based on Lanthanide Complexes

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