A pH-regulated drug delivery dermal patch for targeting infected regions in chronic wounds

Jiang, Hongjie; Ochoa, Manuel; Waimin, Jose; Rahimi, Rahim; Ziaie, Babak

doi:10.1039/c9lc00206e

Cited by 57 publications

(43 citation statements)

References 31 publications

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“…The poly(mAA-co-AAm) hydrogel was synthesized using free radical polymerization similar to reported procedures but with significant optimization [22]. These changes included reducing the material mechanical strength to provide a more spreadable product useful for topical applications and improving pH-responsive properties.…”

Section: Preparation Of Ph-responsive Hydrogelmentioning

confidence: 99%

“…The average pH of healthy skin falls in the range of 4-6; however, the pH is elevated in the presence of bacterial colonization of a wound [21]. Depending on the extent of the infection, the pH becomes alkaline, reaching 7.3-9.8 [22]. A "smart" hydrogel system that is capable of selectively releasing embedded AgNPs in response to wound pH changes would present a major advance in the delivery of AgNPs.…”

Section: Introductionmentioning

confidence: 99%

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pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

et al. 2021

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Persistent wound infections have been a therapeutic challenge for a long time. Current treatment approaches are mostly based on the delivery of antibiotics, but these are not effective for all infections. Here, we report the development of a sensitive pH-responsive hydrogel that can provide controlled, pH-triggered release of silver nanoparticles (AgNPs). This delivery system was designed to sense the environmental pH and trigger the release of AgNPs when the pH changes from acidic to alkaline, as occurs due to the presence of pathogenic bacteria in the wound. Our results show that the prepared hydrogel restricts the release of AgNPs at acidic pH (pH = 4) but substantially amplifies it at alkaline pH (pH = 7.4 and pH = 10). This indicates the potential use of the hydrogel for the on-demand release of Ag+ depending on the environmental pH. In vitro antibacterial studies demonstrated effective elimination of both Gram-negative and positive bacteria. Additionally, the effective antibacterial dose of Ag+ showed no toxicity towards mammalian skin cells. Collectively, this pH-responsive hydrogel presents potential as a promising new material for the treatment of infected wounds.

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Section: Preparation Of Ph-responsive Hydrogelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

et al. 2021

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“…For example, an electric field can induce temperature increment and resultant deformation of a temperature‐responsive hydrogel via Joule heating or dielectric heating. In addition, the generation of hydroxyl ion and the resultant increment of the pH value through electrochemical reaction around cathode can stimulate the deformation of pH‐responsive hydrogels . In other cases, the deformation of a redox‐responsive hydrogel can be triggered electrochemically …”

Section: Stimuli‐responsive Shape‐deforming Hydrogelsmentioning

confidence: 99%

Hydrogel‐Based Artificial Muscles: Overview and Recent Progress

Park

Kim

2020

Advanced Intelligent Systems

119

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Artificial muscles are promising as an intelligent material that can replace conventional power systems to reproduce the motion of a living organism. Among various building materials, hydrogels have great advantages as artificial muscles, such as responsiveness to a wide range of stimuli, large volume deformation, and sensitivity. However, conventional hydrogel actuators that generate only isotropic volume change in response to an external stimulus cannot be considered as artificial muscles because complex deformations are not possible. Instead, programmed complex deformations originated from a rationally designed anisotropic structure are desired in artificial muscles. Herein, recent approaches for constructing stimuli‐responsive hydrogels with an anisotropic structure, thereby enabling a directional complex motion to mimic a muscle are reviewed. First, stimuli‐responsive shape‐deforming hydrogels as a main building matrix are categorized according to stimulating external signals. The representative methods for modulating the isotropic structure of a hydrogel into various anisotropic structures, such as multilayer structure, linearly oriented structure, and patterned structure are discussed. Finally, the recent strategies to achieve muscle‐like motion of hydrogels by combining stimuli responsiveness and anisotropic structures for translation from elementary contraction and expansion to programmed deformations, such as multidirectional bending, directionally amplified deformation, and compositive programmed motion, are covered.

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“…In wound healing, the pH value is suggested as a parameter for both diagnostic and theranostic purposes [8]. Moreover, recent advances in the field of stimuli-responsive drug delivery [9,10] allow for utilization of the pH as an endogenous trigger for drug release in wound healing [11] and solid tumors [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Berkmann

Martin

Ellinghaus

et al. 2020

IJMS

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Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this regenerative tissue has not been studied to date. Thus, in this study, we aimed to unravel the extent and pattern of acidification in vivo during the early phase post musculoskeletal injury. Local pH changes after fracture and muscle trauma were measured simultaneously in two pre-clinical animal models (sheep/rats) immediately after and up to 48 h post injury. The rat fracture hematoma was further analyzed histologically and metabolomically. In vivo pH measurements in bone and muscle hematoma revealed a local acidification in both animal models, yielding mean pH values in rats of 6.69 and 6.89, with pronounced intra- and inter-individual differences. The metabolomic analysis of the hematomas indicated a link between reduction in tricarboxylic acid cycle activity and pH, thus, metabolic activity within the injured tissues could be causative for the different pH values. The significant acidification within the early musculoskeletal hematoma could enable the employment of the pH for novel, sought-after treatments that allow for spatially and temporally controlled drug release.

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A pH-regulated drug delivery dermal patch for targeting infected regions in chronic wounds

Abstract: A low-cost, passive, and flexible dermal patch using wound pH to regulate topical drug delivery in chronic wounds.

Cited by 57 publications

References 31 publications

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

Hydrogel‐Based Artificial Muscles: Overview and Recent Progress

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

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