A pH-responsive drug delivery system based on ethylenediamine bridged periodic mesoporous organosilica

Parambadath, Surendran; Mathew, Aneesh; Barnabas, Mary Jenisha; Ha, Chang‐Sik

doi:10.1016/j.micromeso.2015.05.027

Cited by 29 publications

(17 citation statements)

References 39 publications

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“…B) TEM micrographs displaying the variety of morphologies and structures of MONs and PMO NPs for biomedical applications. Reproduced with permissions from American Chemical Society, Royal Society of Chemistry, Elsevier, Springer, and Wiley …”

Section: Synthesis and Propertiesmentioning

confidence: 99%

“…The incorporation of ethane (Figure A, see images A1 , B1 , A4 , B4 , C4 , D4 ), ethylene ( E4 , F4 ), benzene groups ( C1 , A5 , B5 , C5 , D5 , E5 , F5 ) and their various combinations ( C6 , D6 ) leads to tunable hydrophobicity/hydrophilicity in the pore walls allowing the loading of hydrophobic or hydrophilic drugs in huge contents (600–1200 mg of drug per gram of NPs) . Unlike silica which has an isoelectric point around 2 and 3, it was demonstrated that PMO NPs become positively charged near pH 5.5, which was harnessed for the autonomous pH‐controlled release and delivery of drugs with various PMO NPs (see the structures of D1 , E1 , F1 in Figure A). Biodegradable organosilica nanovehicles can be prepared by adding disulfide ( D2 , E2 , F2 , B6 ), tetrasulfide ( A3 , B3 , C3 , D3 , E6 ), and oxamide bridging groups ( F6 ) into the pore walls of MONs or PMO NPs.…”

Section: Synthesis and Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

471

349

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Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.

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Section: Synthesis and Propertiesmentioning

confidence: 99%

Section: Synthesis and Propertiesmentioning

confidence: 99%

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

471

349

View full text Add to dashboard Cite

show abstract

“…Therefore, MONs can also act as drug-delivery systems (DDSs). [ 94,205,211,[230][231][232][233][234][235][236][237][238] The organic fragments within the framework can bring tunable hydrophobicity/hydrophilicity as well as specifi c host-guest interactions with guest molecules, showing more advantages and specifi c behaviors regarding encapsulation, delivery, and release of drug molecules compared to MSNs.…”

Section: Mons For Drug/gene Deliverymentioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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“…Also, a few PMO drug delivery systems have been reported. [27][28][29] However, gated PMO drug delivery systems to specifically control the release of therapeutics are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

Cheng¹,

Li²,

Lin³

et al. 2018

IJN

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IntroductionFor an ideal drug delivery system, the outstanding drug-loading capacity and specific control of the release of therapeutics at the desired lesions are crucial. In this work, we developed a triple-responsive nanoplatform based on copper sulfide (CuS)-capped yolk−shell-structured periodic mesoporous organosilica nanoparticles (YSPMOs) for synergetic chemo-photothermal therapy.MethodsHerein, the YSPMOs were employed as a drug carrier, which exhibited a high doxorubicin (DOX) loading capacity of 386 mg/g. In this controlled-release drug delivery system, CuS serves as a gatekeeper to modify YSPMOs with reduction-cleavable disulfide bond (YSPMOs@CuS). CuS could not only avoid premature leakage in the delivery process, but also endowed the excellent photothermal therapy (PTT) ability.ResultsUpon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intracellular acidic environment and external laser irradiation. Such a precise control over drug release, combined with the photothermal effect of CuS nanoparticles, is possessed by synergistic chemo-photothermal therapy for cancer treatment. Both in vitro and in vivo experimental data indicated that the synergistic effect of YSPMOs(DOX)@CuS showed efficient antitumor effect. In addition, low systemic toxicity was observed in the pathologic examinations of liver, spleen, lungs, and kidneys.ConclusionThis versatile nanoplatform combination of PTT, chemotherapeutics, and gating components shows general potential for designing multifunctional drug delivery systems.

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A pH-responsive drug delivery system based on ethylenediamine bridged periodic mesoporous organosilica

Cited by 29 publications

References 39 publications

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

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