A pH-responsive drug nanovehicle constructed by reversible attachment of cholesterol to PEGylated poly(l-lysine) via catechol–boronic acid ester formation

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

“…4). In terms of the fluorescence intensity inside HeLa cells, it was shown that DOX-loaded NP2 can be effectively taken up by the cells regardless of NH 4 Cl presence and few influences of NH 4 Cl treatment were detectable on the cellular uptake. Nevertheless, the NH 4 Cl treatment significantly affected the intracellular distribution of the internalized DOX.…”

Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery

“…The formed assemblies could be loaded with FITC-labelled proteins, which could subsequently be released in vitro in response to endosomal acidic pH values or excess fructose through transesterification (Figure 7) [61]. Similarly, Zhuo et al used PEG- b -P(Lys- co -LysCA) in combination with BA-modified cholesterol moieties to encapsulate poorly water-soluble drug like doxorubicin into a micellar structure and release it upon a decrease in pH [62]. …”

Boronic acid modified fiber optic SPR sensor and its application in saccharide detection

“…sugar) by forming the reversible complexes [8]. And it is successfully used in numerous areas such as sensor technology [9][10][11][12], drug delivery [13,14], affinity chromatography [15] and biological research [16][17][18]. Most of the interactions between the boronic acid and saccharide are well performed in basic solution (pH > 8.5).…”