A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing

Zhang, Ziwen; Wang, Jinxia; Luo, Yu; Li, Chunlin; Sun, Yangang; Wang, Kaiyang; Deng, Guoying; Zhao, Linjing; Yuan, Chunping; Lu, Jie; Chen, Ying; Wan, Jian; Liu, Xijian

doi:10.1039/d3tb01567j

Cited by 14 publications

(8 citation statements)

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“…Actually, reactive oxygen species (ROS) are the byproducts of cellular metabolism, which gets instigated as a result of oxidative stress like tissue injury, infection, and inflammation, which damages the tissues. Low levels of ROS are desired in wound healing due to their chemoattractant roles that promote the process of tissue repair. , But chronic inflammation can cause ROS production, leading to a delay in the wound healing process. , As evident from Figure S1, these two inflammatory markers, MDA and glutathione, bear an inverse relationship with each other with the advancement of the wound recovery stage. As shown in Figure , in group 1, the minimum concentration of glutathione and the maximum concentration of malonaldehyde were observed, which might be due to the higher ROS level due to acute injury (Figure S1).…”

Section: Resultssupporting

confidence: 88%

“…From the literature documentation, we learned that a great number of free radicals are generated at the wound site that lead to oxidative stress, subsequent DNA breakage, and protein inactivation, which delay or perturb the recovery process. − ,, …”

Section: Resultsmentioning

confidence: 99%

“…Low levels of ROS are desired in wound healing due to their chemoattractant roles that promote the process of tissue repair. 35,36 But chronic inflammation can cause ROS production, leading to a delay in the wound healing process. 35,36 As evident from Figure S1, these two inflammatory markers, MDA and glutathione, bear an inverse relationship with each other with the advancement of the wound recovery stage.…”

Section: Biochemical Analysismentioning

confidence: 99%

“…35,36 But chronic inflammation can cause ROS production, leading to a delay in the wound healing process. 35,36 As evident from Figure S1, these two inflammatory markers, MDA and glutathione, bear an inverse relationship with each other with the advancement of the wound recovery stage. As shown in Figure 7, in group 1, the minimum concentration of glutathione and the maximum concentration of malonaldehyde were observed, which might be due to the higher ROS level due to acute injury (Figure S1).…”

Section: Biochemical Analysismentioning

confidence: 99%

“…In the past few years, there have been many efforts made on the use of peptide-based hydrogels for wound healing purposes. − To name a few, Hauser and his group made several pioneering contributions . They developed two cysteine-containing peptides as an effective therapeutic for wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Stereogenic Harmony Fabricated Mechanoresponsive Homochiral Triphenylalanine Analogues with Synergistic Antibacterial Performances: A Potential Weapon for Dermal Wound Management

Tiwari,

Gupta,

Shivhare

et al. 2023

ACS Appl. Bio Mater.

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The wound recovery phenomenon remains as one of the long challenging concerns worldwide. In search of userfriendly dressing materials, in this report, we fabricated a rational combinatorial strategy utilizing stereogenic harmony in a triphenylalanine fragment and appending it to δ-amino valeric acid at the N-terminus (hydrogelators I−VII) such that a potential scaffold could be fished out from the design. Our investigations revealed that all the hydrogelators displayed not only excellent selfhealing performance as well as high mechanical strength at physiological pH but also mechanical stress-triggered gel−sol−gel transition properties. The structural and morphological investigation confirmed the presence of β-sheet-like assemblies stabilized by intermolecular H-bonding and π−π interactions. Moreover, these scaffolds showed substantial antibacterial as well as antifungal efficacy against common wound pathogens, i.e, four Gram-positive bacteria (Staphylococcus aureus, Streptococcus mutans, B. subtilis, E. fecalis), four Gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, P. aerugonosa, Proteus spp.), and two fungal strains (C. albicans and A. niger). The manifestation of consistent antioxidant properties might be due to the enhancement of amphiphilicity in hydrogelators, which has led to the generation of reactive oxygen species (ROS) in a facile manner, a probable mechanism to damage the microbial membrane, the driving force behind the antimicrobial efficacy. Also, the constructs exhibited proteolytic resistance and remarkable biocompatibility toward mammalian cells. Thus, based on the above benchmarks, the homochiral hydrogelator IV was seived out from a pool of seven, and we proceeded toward its in vivo evaluation using full-thickness excisional wounds in Wister rats. The scaffolds also accentuated the re-epithelialization as well in comparison to the negative control, thereby facilitating the wound closure process in a very short span of time (10 days). Overall, our in vitro and in vivo analysis certifies hydrogelator IV as an ideal dressing material that might hold immense promise for future wound care management.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%

Section: Biochemical Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stereogenic Harmony Fabricated Mechanoresponsive Homochiral Triphenylalanine Analogues with Synergistic Antibacterial Performances: A Potential Weapon for Dermal Wound Management

Tiwari,

Gupta,

Shivhare

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

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Development of HEMA‐Succinic Acid‐PEG Bio‐Based Monomers for High‐Performance Hydrogels in Regenerative Medicine

Rayat Pisheh,

Sabzevari,

Ansari

et al. 2024

Biopolymers

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In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate‐succinic acid‐polyethylene glycol 200 (HEMA‐Suc‐PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2 g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA‐Suc‐PEG and 0.2 g of PEGDA has the potential to be used in the cardiovascular system.

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Recent Advances in Smart Self‐Assembled Bioinspired Hydrogels: A Bridging Weapon for Emerging Health Care Applications from Bench to Bedside

Ahuja,

Shivhare,

Konar

2024

Macromol. Rapid Commun.

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Stimuli‐responsive low molecular weight hydrogel interventions for Biomedical challenges are a rapidly evolving paradigm in the bottom‐up approach in recent years. Peptide‐based self‐assembled nano biomaterials present safer alternatives to their non‐degradable counterparts as they are amalgamated with unique properties such as biocompatibility, biodegradability, tunable macromolecular structure, adjustable mechanical integrity, and many more, as demanded for today's most urged clinical needs. Although a plethora of work has already been accomplished and significant progress has been realized using these platforms, programming hydrogelators with appropriate functionalities requires a better understanding as the impact of the macromolecular structure of the peptides and subsequently, their self‐assembled nanostructures remain highly unidentified. As such this review focuses on two different aspects: Firstly, the underlying guidelines and principles for building multi‐faceted biomimetic strategies to tailor scaffolds that would lead to hydrogelation, taking into consideration a set of several N‐terminus protecting groups/amphiphiles and their utility along with the overview of the role of non‐covalent interactions that are the key components of various self‐assembly processes. In the second section, we aim to bring together how incorporating nature‐inspired properties into hydrogels, we are successful in bringing to the forefront, the recent achievements with designer assembly contributed by scientists and ours, concerning their self‐aggregation behaviour and applications mainly in the biomedical arena like drug delivery carrier design, antimicrobial, anti‐inflammatory as well as wound healing materials. Furthermore, we anticipate that this article will provide a conceptual demonstration of the different approaches taken towards the construction of these task‐specific designer hydrogels. Finally, a collective effort among the material scientists is required to pave the path for the entrance of these intelligent materials into personalized medicine from bench to bedside. This article is protected by copyright. All rights reserved

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A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing

Abstract: As the problem of bacterial resistance and high oxidation level, these severely limits wound healing. Therefore, we constructed a multifunctional platform of chitosan quaternary ammonium salts (QCS) / polyvinyl alcohol...

Cited by 14 publications

References 73 publications

Stereogenic Harmony Fabricated Mechanoresponsive Homochiral Triphenylalanine Analogues with Synergistic Antibacterial Performances: A Potential Weapon for Dermal Wound Management

Stereogenic Harmony Fabricated Mechanoresponsive Homochiral Triphenylalanine Analogues with Synergistic Antibacterial Performances: A Potential Weapon for Dermal Wound Management

Development of HEMA‐Succinic Acid‐PEG Bio‐Based Monomers for High‐Performance Hydrogels in Regenerative Medicine

Recent Advances in Smart Self‐Assembled Bioinspired Hydrogels: A Bridging Weapon for Emerging Health Care Applications from Bench to Bedside

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