A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy

Debele, Tilahun Ayane; Lee, Kuan Yi; Hsu, Ning Yu; Chiang, Yen-Ting; Lu, Yu; Shen, Yao; Lo, Chun Liang

doi:10.1039/c7tb01031a

Cited by 44 publications

(14 citation statements)

References 47 publications

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“…The results above about the drug loading and controlled release indicate that an amorphous hydrophobic block of PDL, compared to a semicrystalline hydrophobic block of PCL, in the amphiphilic block copolymers not only gives higher drug-loading capacity, but also promotes the drug release [41]. In addition, shorter PCL blocks benefits faster and a higher extent of drug release.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

2018

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We report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.

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Section: Resultsmentioning

confidence: 99%

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

2018

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“…As a response to low tumoral pH, the pH-sensitive polymers (e.g., poly-β-aminoester and polyhistidines) or pH-dependent degradable linkers (e.g., hydrazones) of micelle-forming polymers may lead micellar disassembly and trigger the release of the encapsulated cargo. This phenomenon is used for various anticancer agents, including gambogic acid [ 104 ], paclitaxel [ 105 ], doxorubicin [ 106 , 107 ], and gefitinib [ 108 ].…”

Section: Nddss In the Delivery Of Nrf2 Modulators For Cancer Therapymentioning

confidence: 99%

Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy

et al. 2021

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The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery of new therapeutic agents and potential drug delivery systems. In particular, the introduction of nano-sized drug delivery systems (NDDSs) has opened new horizons for effective cancer treatment. These are considered potential systems that provide deep tissue penetration and specific drug targeting. On the other hand, nuclear factor erythroid 2-related factor 2 (NRF2)-based anticancer treatment approaches have attracted tremendous attention and produced encouraging results. However, the lack of effective formulation strategies is one of the factors that hinder the clinical application of NRF2 modulators. In this review, we initially focus on the critical role of NRF2 in cancer cells and NRF2-based anticancer treatment. Subsequently, we review the preparation and characterization of NDDSs encapsulating NRF2 modulators and discuss their potential for cancer therapy.

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“…In other words, the intracellular ROS would be self-regenerated and ampli ed. Finally, TOS was less toxic to normal cells and shows speci c anticancer activities to various cancers [21] . DOX could be encapsulated by hydrophobic interaction with TOS and methionine and electrostatic attraction with DMA.…”

Section: Introductionmentioning

confidence: 97%

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Zhang

Zhu

Miao

et al. 2020

Preprint

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Abstract Background: The enhancement of tumor retention and cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform, armed with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS)-induced drug release, was constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle.Results: The surface charge of this system can be converted from negative to positive from pH 7.4 to pH 6.8, which facilitates the cellular uptake. In addition, methionine-based system was dissociated in a ROS-rich and acidic intracellular environment, resulting in the release of DOX and α-tocopheryl succinate (TOS). Then, the exposed TOS segments can further induced the generation of ROS, leading to self-amplifiable disassembly of the micelles and drug release. Conclusions: We confirmed efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro. The system exhibited outstanding tumor inhibition capability in vivo, indicating that dual stimuli nanosytem has great potential as an anticancer drug delivery platform.

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A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy

Abstract: pH-Sensitive rod-like micelles were designed to improve drug release, to increase cytotoxicity towards cancer cells, and to reduce cytotoxicity towards normal cells.

Cited by 44 publications

References 47 publications

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

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