A pharmacoeconomic assessment of recombinant tissue plasminogen activator therapy for acute ischemic stroke in a tertiary hospital in China

Yan, Xiaofeng; Hu, Hongtao; Liu, Sizhu; Sun, Yu-heng; Gao, Xin

doi:10.1179/1743132814y.0000000447

Cited by 6 publications

(11 citation statements)

References 25 publications

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“…Among 15 original articles reviewed, six studies were from the US(9, 24–28), two from the United Kingdom (UK)(29, 30), two from Australia(31, 32), two from China(33, 34), and one each from Canada(35), New Zealand(36), Denmark(37), and Spain(38). Nine of them used the payers’ perspective or health care system perspective, and four studies used the societal perspective while two studies did not clearly mention it.…”

Section: Resultsmentioning

confidence: 99%

“…In Table 1, nine of 15 studies investigated the cost-effectiveness of IV rtPA therapy within 0–3 hours after stroke onset(9, 24, 26, 28, 30, 32, 35, 37, 38), two studies within 3–4.5 hours(25, 27), three studies within 0–4.5 hours(31, 34, 36), and one study within 0–6 hours(29, 33) (Figure 1). The first study that examined cost-effectiveness of IV rtPA was published in 1998, two years after the FDA approval.…”

Section: Resultsmentioning

confidence: 99%

“…Among them, the five studies were the studies of IV rtPA within 3–4.5 hours or 0–4.5 hours after the onset of stroke. (25, 27, 31, 34, 36) The remaining three studies published during this period were US studies looking at the 0–3 hours’ time window to investigate up-to-date cost-effectiveness of IV rtPA(24) or state specific cost-effectiveness of IV rtPA(26), and Chinese study examining the 0–6 hours cost-effectiveness of IV rtPA(33). …”

Section: Resultsmentioning

confidence: 99%

“…(29) The Chinese study by Yan and co-workers also showed that IV rtPA within 6 hours increased both cost and utility and cost-effective within 14 days after the stroke. (33)…”

Section: Resultsmentioning

confidence: 99%

“…Some studies mentioned a lack of generalizability because of data limitations. (24–26, 28, 33, 35) It was also pointed out that some studies used multiple data sources because of limited data. (24, 25) Lack of long-term mortality and cost data as well as insufficient up-to-date outcome and cost data were also mentioned as limitations.…”

Section: Resultsmentioning

confidence: 99%

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A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke

Joo¹,

Wang

George

2017

Stroke Vasc Neurol

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BackgroundIntravenous recombinant tissue plasminogen activator (IV rtPA) is recommended treatment for patients with acute ischaemic stroke, but the cost-effectiveness of IV rtPA within different time windows after the onset of acute ischaemic stroke is not well reviewed.AimsTo conduct a literature review of the cost-effectiveness studies about IV rtPA by treatment times.Summary of reviewA literature search was conducted using MEDLINE, EMBASE, CINAHL and Cochrane Library, with the keywords acute ischemic stroke, tissue plasminogen activator, cost, economic benefit, saving and incremental cost-effectiveness analysis. The review is limited to original research articles published during 1995–2016 in English-language peer-reviewed journals. We found 16 studies meeting our criteria for this review. Nine of them were cost-effectiveness studies of IV rtPA treatment within 0–3 hours after stroke onset, 2 studies within 3–4.5 hours, 3 studies within 0–4.5 hours and 2 studies within 0–6 hours. IV rtPA is a cost-saving or a cost-effectiveness strategy from most of the study results. Only one study showed incremental cost-effectiveness ratio of IV rtPA within 1 year was marginally above US$50 000 per quality-adjusted life year threshold. IV rtPA within 0–3 hours after stroke led to cost savings for lifetime or 30 years and IV rtPA within 3–4.5 hours after stroke increased costs but still was cost-effective.ConclusionsThe literature generally showed that IV rtPA was a dominant or a cost-effective strategy compared with traditional treatment for patients with acute ischaemic stroke without IV rtPA. The findings from the literature lacked generalisability because of limited data and various assumptions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…(29) The Chinese study by Yan and co-workers also showed that IV rtPA within 6 hours increased both cost and utility and cost-effective within 14 days after the stroke. (33)…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke

Joo¹,

Wang

George

2017

Stroke Vasc Neurol

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Quality of Health Economic Evaluations in Mainland China: A Comparison of Peer-Reviewed Articles in Chinese and in English

Cheng

Zhang

Zhong

et al. 2021

Appl Health Econ Health Policy

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Background Health and education are two closely related factors that affect human development. A limited number of studies have been conducted in China, most of which have been based on small sample sizes and with inconsistent results. The study investigates the association between mortality rate and educational level in China based on the sixth national population census in 2010.Methods This is large-scale population study based on the nationally administrated data sets of population census in 2010, 2000 and 1990. The 2010 census covered a total population of 1 332 810,869 in China. ResultsIn general, standardized mortality rate decreased as educational level increased. The standardized mortality rate is higher among males than among females with equivalent educational levels. The standardized mortality rate in all the educational groups declined to varying degrees from 1990. 2000 to 2010. The standardised mortality rate declined with increasing educational levels from no education to university undergraduate groups in 1990, 2000 and 2010. The standardized mortality rate declined as the degree of education increased in cities, towns, and villages, but gradually increased at the same educational level from cities, towns, to villages in general. The difference in each region is considerable and the population quality of the developed area is generally high. The percentage of the uneducated population to the total population aged 15 years and over (%) was positively correlated with the standardized mortality rate. By contrast, the percentage of the population with a high school education to the total population aged 6 years and over (%) was negatively correlated with the standardized mortality rate.

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Adapting Clinical Practice of Thrombolysis for Acute Ischemic Stroke Beyond 4.5 Hours: A Review of the Literature

Simpkins

Tahsili-Fahadan

Buchwald

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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A pharmacoeconomic assessment of recombinant tissue plasminogen activator therapy for acute ischemic stroke in a tertiary hospital in China

Abstract: Intravenous rt-PA was associated with lower patients' disabilities, fewer in-hospital days, and comparable total costs compared to conservative therapy for the management of AIS.

Cited by 6 publications

References 25 publications

A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke

A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke

Quality of Health Economic Evaluations in Mainland China: A Comparison of Peer-Reviewed Articles in Chinese and in English

Adapting Clinical Practice of Thrombolysis for Acute Ischemic Stroke Beyond 4.5 Hours: A Review of the Literature

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