A pharmacokinetic analysis program (multi) for microcomputer.

Yamaoka, Kiyoshi; Tanigawara, Yusuke; Nakagawa, Terumichi; Uno, Toyozo

doi:10.1248/bpb1978.4.879

Cited by 2,312 publications

(975 citation statements)

References 3 publications

Supporting

Mentioning

973

Contrasting

Order By: Relevance

“…The radioactivity of all samples and that of the plasma was normalised to the percentage of dose or percentage of dose per millilitre, respectively. Plasma concentrations were analysed by a biexponential function using the non-linear least-squares computer program MULTI [28]. The two-compartment model was chosen according to the Akaike information criterion.…”

Section: Methodsmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

View full text Add to dashboard Cite

Aims/hypothesis: Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. Methods: Glycolaldehyde-modified BSA (GA-BSA) and methylglyoxalmodified BSA (MG-BSA) were prepared as model AGE proteins, and their in vivo plasma clearance was examined in mice, and renal uptake by in vitro studies with isolated renal mesangial cells. Results: Both 111 In-GA-BSA and 111

show abstract

Section: Methodsmentioning

confidence: 99%

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

et al. 2005

View full text Add to dashboard Cite

show abstract

“…31) The C max and T max values were obtained from the milnacipran concentration-time curves, and the area under the milnacipran concentration versus time curve (AUC) value was calculated by moment analysis. The plasma and CSF concentrations of milnacipran after i.v.…”

Section: Pharmacological Study Using the Forced Swimming Testmentioning

confidence: 99%

Intranasal Administration of Milnacipran in Rats: Evaluation of the Transport of Drugs to the Systemic Circulation and Central Nervous System and the Pharmacological Effect

Uchida

Katoh

Mori

et al. 2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

“…9) Estimation of Pharmacokinetic Parameters To calculate the pharmacokinetic parameters, namely, the Michaelis constant (K m ), maximum velocity (V max ), and IC 50 , of testosterone metabolism by human recombinant CYP3A4, Eqs. 1 and 2 were fitted to the observed data by non-linear least-squares regression analysis with the MULTI program 13) :…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Effects of Juices Prepared from Individual Vegetables on CYP3A4 Activity in Recombinant CYP3A4 and LS180 Cells

Tsujimoto

Agawa

Ueda

et al. 2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Human intestinal absorption and drug metabolism vary to a large extent among individuals. For example, CYP3A4 activity has large individual variation that cannot be attributed to only genetic differences. Various flavonoids in vegetables, such as kaempferol and quercetin, possess inhibitory effects, and some vegetable and fruit juices have also been found to inhibit CYP3A4 activity. Therefore, differences in daily intake of flavonoid-containing vegetables may induce individual variation in intestinal bioavailability. To identify a vegetable that strongly inhibits CYP3A4, we investigated the effects of juices, prepared from individual vegetables, on CYP3A4 activity using recombinant CYP3A4 and LS180 cells in this study. Nine vegetable juices (cabbage, Japanese radish, onion, tomato, eggplant, carrot, Chinese cabbage, green pepper, and lettuce), were prepared and recombinant CYP3A4 and LS180 cells were used for evaluation of CYP3A4 activity. Metabolism to 6β-hydroxytestosterone by recombinant CYP3A4 was strongly inhibited by cabbage, onion, and green pepper juices, and cabbage and green pepper juices significantly inhibited CYP3A4 activity in a preincubation time-dependent manner. In addition, CYP3A4 activity in LS180 cells was significantly inhibited by cabbage and onion juices. In conclusion, this study showed that juices prepared from some individual vegetables could significantly inhibit CYP3A4 activity. Therefore, variation in the daily intake of vegetables such as cabbage and onion may be one of the factors responsible for individual differences in intestinal bioavailability.

show abstract

A pharmacokinetic analysis program (multi) for microcomputer.

Cited by 2,312 publications

References 3 publications

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A)

Intranasal Administration of Milnacipran in Rats: Evaluation of the Transport of Drugs to the Systemic Circulation and Central Nervous System and the Pharmacological Effect

Inhibitory Effects of Juices Prepared from Individual Vegetables on CYP3A4 Activity in Recombinant CYP3A4 and LS180 Cells

Contact Info

Product

Resources

About