A pharmacological study of cefaclor in the newborn infant

Chin, Kang; Kerr, Murray; Cockburn, F.; McAllister, T A

doi:10.1185/03007998109114258

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…The results reported a decrease in C max in the fed state, which can be true also for the neonatal population [ 78 , 79 ]. PK of cefaclor was studied in 10 newborns, a mean peak serum concentration of 7.7 μg/mL was achieved at 1 h after an oral dose of 7.5 mg/kg [ 80 ]. For plasma concentrations of cefaclor, the same effects of fed and fasting states were detected as those for cefadroxil and cephradine [ 81 ].…”

Section: General Considerations On Neonate’s Pharmacokineticsmentioning

confidence: 99%

Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants

et al. 2023

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Neonatal Infections are among the most common reasons for admission to the intensive care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic therapy of NS recommended by current international guidelines includes benzylpenicillin, ampicillin/amoxicillin, and aminoglycosides (gentamicin). The rise of antibacterial resistance precipitates the growth of the use of antibiotics of the Watch (second, third, and fourth generations of cephalosporines, carbapenems, macrolides, glycopeptides, rifamycins, fluoroquinolones) and Reserve groups (fifth generation of cephalosporines, oxazolidinones, lipoglycopeptides, fosfomycin), which are associated with a less clinical experience and higher risks of toxic reactions. A proper dosing regimen is essential for effective and safe antibiotic therapy, but its choice in neonates is complicated with high variability in the maturation of organ systems affecting drug absorption, distribution, metabolism, and excretion. Changes in antibiotic pharmacokinetic parameters result in altered efficacy and safety. Population pharmacokinetics can help to prognosis outcomes of antibiotic therapy, but it should be considered that the neonatal population is heterogeneous, and this heterogeneity is mainly determined by gestational and postnatal age. Preterm neonates are common in clinical practice, and due to the different physiology compared to the full terms, constitute a specific neonatal subpopulation. The objective of this review is to summarize the evidence about the developmental changes (specific for preterm and full-term infants, separately) of pharmacokinetic parameters of antibiotics used in neonatal intensive care units.

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