A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Armodafinil for Excessive Sleepiness Associated With Jet Lag Disorder

Jet Lag and Shift Work

“…Armodafinil at a dose of 150 mg per day increased wakefulness after simulated eastbound travel through 6 time zones in 143 participants, compared with 142 controls, and was generally well tolerated. 31 …”

Effect Of Armodafinil On Cortical Activity And Working Memory In Patients With Residual Excessive Sleepiness Associated With CPAP-Treated OSA: A Multicenter FMRI Study

“…[15][16][17][59][60][61] Lack of a response to both objective and subjective measures has several possible explanations. The study may have been underpowered given the inter-individual variability in sensitivity to sleepiness seen in OSA patients (for given degrees of sleep apnea severity) and experimental sleep deprivation.…”

Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: Implication of the PKA pathway

“…In the intestinal epithelium, they play a fundamental role hindering the invasion of tissues by pathogens (Bonazzi and Cossart, 2011). Furthermore, TJs are key components of the integrity of the blood-brain barrier, essential to avoid neurological dysfunction (Rosenberg et al, 2011).…”