1999
DOI: 10.1159/000026957
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A Phase I/II Study of Dose-Escalated Ifosfamide plus Carboplatin Combination for Advanced Ovarian Carcinoma

Abstract: Background: Advanced ovarian cancer is often a fatal disease, despite good initial response to chemotherapy. Dose-intense schedules have been reported, but failed to demonstratesignificant breakthrough. This study evaluates high-dose ifosfamide (IFO) plus carboplatin (CBDCA) in advanced ovarian cancer. Patients and Methods:Twenty-eight patients entered this phase I/II study. All had diagnostic laparotomy and maximal debulking if possible. IFO and CBDCA were given every 3 weeks for 6 courses or less, if there w… Show more

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