A phase I/II trial of neoadjuvant chemotherapy with cisplatin and vinorelbine followed by accelerated irradiation for patients with inoperable nonsmall cell lung carcinoma

Vinorelbine for non-small cell lung cancer

“…Moreover, vinorelbine has shown encouraging activity and an acceptable toxicity profile in several Phase II studies of sequential [52][53][54] or concurrent [55][56][57][58] chemoradiotherapy or induction chemotherapy followed by concurrent chemo-radiotherapy [59,60].…”

Vinorelbine in the Treatment of Non-Small Cell Lung Cancer

“…So there is a explored the feasibility of the combination of thoracic radiotherapy and concurrent vinorelbine administered daily as a radiosensitizer. Moreover., vinorelbine has been included in several studies of sequential [73][74][75][76] or concurrent [77][78][79] chemo-radiotherapy or induction chemotherapy followed by concurrent chemotherapy plus radiotherapy [80][81][82] with encouraging activity and an acceptable toxicity profile. A randomized phase II study [82]., investigating gemcitabine or paclitaxel or vinorelbine with cisplatin as induction chemotherapy and concomitant chemo-radiotherapy for unresectable stage III patients., showed similar response rates and median survival in all arms.…”

“…Another phase II study [84] randomized patients to concurrent or sequential radio-chemotherapy with vinorelbine plus cisplatin and reported higher response rates (85% vs 45% ORs., respectively) but also a higher incidence of hematologic toxicity and radiation-induced esophagitis with the concurrent approach. Table 7 summarises phase II studies of combined chemo-radiotherapy including vinorelbine [73][74][75][76][77][78][79][80][81][82][83].…”