2021
DOI: 10.1101/2020.12.26.20248062
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A phase I/II trial to treat massive Africanized honeybee (Apis mellifera) stings using the new apilic antivenom

Abstract: Safety, optimal minimum dose, and, preliminary effectiveness of a new generation Africanized honeybees (Apis mellifera) antivenom (AAV) were evaluated. A phase I/II, multicenter, non- randomized, single-arm clinical trial involving 20 participants showing multiple stings were studied. Participants have received either 2 to 10 vials of AAV based on the stings number together with a predefined adjuvant, symptomatic, and complementary treatment schedule. The primary safety endpoint was the presence of early adver… Show more

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