A phase I study of AGRO100 in advanced cancer

Laber, Damian A.; Choudry, M. A.; Taft, B.; Bhupalam, L.; Sharma, Vivek R.; Hendler, F. J.; Barnhart, Kerry M.

doi:10.1200/jco.2004.22.90140.3112

Cited by 9 publications

(15 citation statements)

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“…AGRO100 is the first aptamer to be tested in humans for treatment of cancer. In total, 67% of the patients exhibited a stable disease profile after Phase I trial [83] . The drug was administered intravenously and toxicity was assessed after regular intervals.…”

Section: Anticancer Aptamermentioning

confidence: 99%

Therapeutic applications of aptamers

Kaur

Roy

2007

Expert Opinion on Investigational Drugs

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Aptamers constitute a new class of oligonucleotides that have gained therapeutic importance. With the approval of the first aptamer drug, pegaptanib, interest in this class of oligonucleotides, often referred to as 'chemical antibodies', has increased. This article discusses aptamers in relation to other oligonucleotide molecules such as antisense nucleotides, short inhibitory sequences, ribozymes and so on. The development of pegaptanib is looked at from the point of view of the challenges faced in converting aptamers into therapeutic molecules. Cases of other aptamers, which show promise as drugs, are discussed in slightly greater detail. Comparison with antibodies and small molecules, which have hitherto held monopoly in this area, is also made.

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Section: Anticancer Aptamermentioning

confidence: 99%

Therapeutic applications of aptamers

Kaur

Roy

2007

Expert Opinion on Investigational Drugs

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“…Seventeen patients received Auf{Ol()() and results indicated that AuftOlOO had little toxicity and no serious side effects [38]. An analysis of the efficacy of the drug revealed seven patients showed disease stabilization lasting between ~ and i 5 months.…”

Section: Properties Of Guanine-rich Oligonucleotidesmentioning

confidence: 99%

“…They exhibit potent antiproliferative properties in several malignant cell lines, inducing 3-phase ceil cycle arrest and ce11 death exc1usive1y in cancer celts, teaving non-maiignant cells primarily unaffected [35]. GROs have also demonstrated considerable potential in phase I clinical trials in patients with advanced cancer, showing that the drug is well tolerated and exhibits promising cHnical activity [38]. The primary target of CJ"ROs has previously been identified as nucleolin [34], which is a multifunctional protein involved in a variety of cellular processes like ribosome biogenesis [40,43], DNA replication [44], cell growth and proliferation [40][41][42], apoptosis [46,47], and cytokinesis and nuclear division [4j].…”

Section: Chapter V Global Assessment Of Gene and Protein Expression Imentioning

confidence: 99%

“…We have previously reported guanine-rich oligonucleotides (GROs) exhibiting potent antiproHfurative properties in several ma1fgnant ce11 tines [34][35][36][37], and demonstrating considerable potential as a novel therapeutic agent for cancer [38].…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

“…GROs exhibit potent antiproliferative properties against several cancer cell lines , and demonstrated the same anticancer effects in an in vivo tumor mouse model ( Figure 6D). Phase I clinical trials have also demonstrated that GROs could be a promising clinical agent against cancer [38]. The antiproliferative activity of GROs apparently has a novel mechanism of action, although some aspects of its function have previously been shown.…”

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confidence: 99%

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Mechanistic studies of guanine-rich oligonucleotides.

Girvan¹,

Allicia²

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Jim, Shahenda and Krista. I will be forever grateful to my parents, Gary and Karen, for their encouragement and sacrifice throughout my entire life to enable my success. I would like to express my gratitude to my sons, Caleb and Joshua, who could tum a bad day into a great one with one smile. I wholeheartedly thank my loving husband, Sonny, for all of his love and support through these years. He has endured my stress with nothing but encouragement, understanding, and motivation to persevere.

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