2024
DOI: 10.1002/cpt.3504
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A Phase I Trial of the Pharmacokinetic Interaction Between Cannabidiol and Tacrolimus

Gerald C. So,
Jessica Bo Li Lu,
Sachiko Koyama
et al.

Abstract: One in six Americans uses cannabidiol‐based or cannabis‐derived products. Cannabidiol is a substrate of CYP3A, but its role as a potential CYP3A inhibitor remains unclear. We hypothesized that cannabidiol would inhibit CYP3A‐mediated metabolism of tacrolimus. This report is an interim analysis of an open‐label, three‐period, fixed‐sequence, crossover study in healthy participants. Participants first received a single dose of tacrolimus 5 mg orally. After washout, participants later received cannabidiol titrate… Show more

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